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dc.contributor.authorGiva, S
dc.contributor.authorFinnegan, J
dc.contributor.authorIhidero, P
dc.contributor.authorMaguire, G
dc.contributor.authorPower, B
dc.contributor.authorKnerr, I
dc.contributor.authorMonavari, A
dc.date.accessioned2019-02-04T15:22:17Z
dc.date.available2019-02-04T15:22:17Z
dc.date.issued2019-01
dc.identifier.urihttp://hdl.handle.net/10147/624086
dc.description.abstractHyperammonaemia is a metabolic disturbance characterized by accumulation of ammonia in the blood. Entry of ammonia into the brain via the blood-brain barrier leads to hyperammonaemic encephalopathy. The causes of hyperammonaemia in paediatric patients vary. We present 3 cases of hyperammonaemia in critically ill children in whom an inborn metabolic disorder was identified and provide insights into the phenotypes, diagnostic approaches and management. In children with acute overwhelming illness and progressive neurological deterioration plasma ammonia measurement should be included in the urgent diagnostic work-up. We here raise the awareness that hyperammonaemia is a metabolic emergency requiring prompt recognition and treatment to avoid subsequent complications.en_US
dc.language.isoenen_US
dc.publisherIrish Medical Journalen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectBLOOD DISORDERSen_US
dc.subjectMETABOLIC DISORDERSen_US
dc.subjectINFANTSen_US
dc.titleHyperammonaemia in Neonates and Young Children: Potential Metabolic Causes, Diagnostic Approaches and Clinical Consequencesen_US
dc.typeArticleen_US
dc.identifier.journalIrish Medical Journalen_US
dc.description.fundingNo fundingen_US
dc.description.provinceLeinsteren_US
dc.description.peer-reviewpeer-reviewen_US
refterms.dateFOA2019-02-04T15:22:18Z


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States