Authors
Morris, Joan KSpringett, Anna L
Greenlees, Ruth
Loane, Maria
Addor, Marie-Claude
Arriola, Larraitz
Barisic, Ingeborg
Bergman, Jorieke E H
Csaky-Szunyogh, Melinda
Dias, Carlos
Draper, Elizabeth S
Garne, Ester
Gatt, Miriam
Khoshnood, Babak
Klungsoyr, Kari
Lynch, Catherine
McDonnell, Robert
Nelen, Vera
Neville, Amanda J
O'Mahony, Mary
Pierini, Anna
Queisser-Luft, Annette
Randrianaivo, Hanitra
Rankin, Judith
Rissmann, Anke
Kurinczuk, Jennifer
Tucker, David
Verellen-Dumoulin, Christine
Wellesley, Diana
Dolk, Helen
Issue Date
2018-01-01Keywords
CONGENITAL ANOMALYPOPULATION HEALTH
Metadata
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Plos OneJournal
Plos OneDOI
10.1371/journal.pone.0194986PubMed ID
29621304Abstract
Surveillance of congenital anomalies is important to identify potential teratogens. This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models. Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing. The annual increasing prevalence of severe congenital heart defects, single ventricle, atrioventricular septal defects and tetralogy of Fallot of 1.4% (95% CI: 0.7% to 2.0%), 4.6% (1.0% to 8.2%), 3.4% (1.3% to 5.5%) and 4.1% (2.4% to 5.7%) respectively may reflect increases in maternal obesity and diabetes (known risk factors). The increased prevalence of cystic adenomatous malformation of the lung [6.5% (3.5% to 9.4%)] and decreased prevalence of limb reduction defects [-2.8% (-4.2% to -1.5%)] are unexplained. For renal dysplasia and maternal infections, increasing trends may be explained by increased screening, and deceases in patent ductus arteriosus at term and increases in craniosynostosis, by improved follow up period after birth and improved diagnosis. For oesophageal atresia, duodenal atresia/stenosis and ano-rectal atresia/stenosis recent changes in prevalence appeared incidental when compared with larger long term fluctuations. For microcephaly and congenital hydronephrosis trends could not be interpreted due to discrepancies in diagnostic criteria. The trends for club foot and syndactyly disappeared once registries with disparate results were excluded. No decrease in neural tube defects was detected, despite efforts at prevention through folic acid supplementation.Item Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0194986
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