The Composition of Human Milk and Infant Faecal Microbiota Over the First Three Months of Life: A Pilot Study.
Authors
Murphy, KieraCurley, David
O'Callaghan, Tom F
O'Shea, Carol-Anne
Dempsey, Eugene M
O'Toole, Paul W
Ross, R PAUL
Ryan, C Anthony
Stanton, Catherine
Issue Date
2017-01-17Keywords
Breast MilkGUT MICROBIA
MICROBIOLOGY
BREASTFEEDING (INFANT)
INFANT
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Scientific ReportsJournal
Scientific ReportsDOI
10.1038/srep40597PubMed ID
28094284Abstract
Human milk contains a diverse array of bioactives and is also a source of bacteria for the developing infant gut. The aim of this study was to characterize the bacterial communities in human milk and infant faeces over the first 3 months of life, in 10 mother-infant pairs. The presence of viable Bifidobacterium and Lactobacillus in human milk was also evaluated. MiSeq sequencing revealed a large diversity of the human milk microbiota, identifying over 207 bacterial genera in milk samples. The phyla Proteobacteria and Firmicutes and the genera Pseudomonas, Staphylococcus and Streptococcus were the predominant bacterial groups. A core of 12 genera represented 81% of the microbiota relative abundance in milk samples at week 1, 3 and 6, decreasing to 73% at week 12. Genera shared between infant faeces and human milk samples accounted for 70-88% of the total relative abundance in infant faecal samples, supporting the hypothesis of vertical transfer of bacteria from milk to the infant gut. In addition, identical strains of Bifidobacterium breve and Lactobacillus plantarum were isolated from the milk and faeces of one mother-infant pair. Vertical transfer of bacteria via breastfeeding may contribute to the initial establishment of the microbiota in the developing infant intestine.Item Type
ArticleLanguage
enISSN
2045-2322ae974a485f413a2113503eed53cd6c53
10.1038/srep40597
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States
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