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    Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding

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    Authors
    Fogarty, H
    Byrne, M
    O’Connell, NM
    Ryan, K
    White, B
    O’Donnell, JS
    Lavin, M
    Issue Date
    2018-05
    Keywords
    DEFICIENCY
    BLOOD
    Local subject classification
    PLASMA
    
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    Show full item record
    Publisher
    Irish Medical Journal
    Journal
    Irish Medical Journal
    URI
    http://hdl.handle.net/10147/623062
    Abstract
    Factor XIII (FXIII) is a plasma clotting protein involved in clot stabilization. Severe FXIII deficiency may present with severe, even fatal bleeding. Critically however, routine coagulation assays may be normal and only specific FXIII assays will detect the abnormality. Herein we discuss a case report of a patient with acquired FXIII deficiency in order to highlight the clinical challenges associated with establishing the diagnosis and discuss the treatment approach. A 70-year-old man presented with a gluteal haematoma despite no preceding personal history of bleeding. Extensive initial haemostatic investigations were normal until a specific FXIII assay showed a marked reduction in FXIII levels. With directed treatment, bleeding episodes ceased and remission was achieved. Clinical awareness of FXIII deficiency is important, so appropriate testing can be implemented in patients with unexplained bleeding diatheses, particularly those in whom bleeding responds poorly to standard replacement therapy.
    Item Type
    Article
    Language
    en
    Collections
    St. James's Hospital

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