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    Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells.

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    RapamycinRegulatesAutophagy.pdf
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    5.502Mb
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    Description:
    OA Article
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    Authors
    Sotthibundhu, Areechun
    McDonagh, Katya
    von Kriegsheim, Alexander
    Garcia-Munoz, Amaya
    Klawiter, Agnieszka
    Thompson, Kerry
    Chauhan, Kapil Dev
    Krawczyk, Janusz
    McInerney, Veronica
    Dockery, Peter
    Devine, Michael J
    Kunath, Tilo
    Barry, Frank
    O'Brien, Timothy
    Shen, Sanbing
    Show allShow less
    Issue Date
    2016
    Keywords
    STEM CELLS
    Local subject classification
    Autophagy
    MeSH
    Autophagy
    Cell Adhesion
    Cell Differentiation
    Cells, Cultured
    Cellular Reprogramming
    Embryoid Bodies
    Germ Layers
    Humans
    Induced Pluripotent Stem Cells
    Sirolimus
    Up-Regulation
    Show allShow less
    
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    Citation
    Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells. 2016, 7 (1):166 Stem Cell Res Ther
    Publisher
    BioMed Central
    Journal
    Stem cell research & therapy
    URI
    http://hdl.handle.net/10147/622960
    DOI
    10.1186/s13287-016-0425-x
    PubMed ID
    27846905
    Additional Links
    https://stemcellres.biomedcentral.com/articles/10.1186/s13287-016-0425-x
    Abstract
    Cellular reprogramming is a stressful process, which requires cells to engulf somatic features and produce and maintain stemness machineries. Autophagy is a process to degrade unwanted proteins and is required for the derivation of induced pluripotent stem cells (iPSCs). However, the role of autophagy during iPSC maintenance remains undefined.
    Item Type
    Article
    Language
    en
    ISSN
    1757-6512
    Sponsors
    This work was supported by Science Foundation Ireland (SFI), Strategic Research Cluster (SRC), grant numbers SFI: 09/SRCB1794 and 09/SRC/ B1794s1, SFI Investigator Programme 13/IA/1787, SFI TIDA program 14/TIDA/2258, and NUI Galway Grant RSU002
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13287-016-0425-x
    Scopus Count
    Collections
    Galway University Hospitals

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