Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells.
Authors
Sotthibundhu, AreechunMcDonagh, Katya
von Kriegsheim, Alexander
Garcia-Munoz, Amaya
Klawiter, Agnieszka
Thompson, Kerry
Chauhan, Kapil Dev
Krawczyk, Janusz
McInerney, Veronica
Dockery, Peter
Devine, Michael J
Kunath, Tilo
Barry, Frank
O'Brien, Timothy
Shen, Sanbing
Issue Date
2016Keywords
STEM CELLSLocal subject classification
AutophagyMeSH
AutophagyCell Adhesion
Cell Differentiation
Cells, Cultured
Cellular Reprogramming
Embryoid Bodies
Germ Layers
Humans
Induced Pluripotent Stem Cells
Sirolimus
Up-Regulation
Metadata
Show full item recordCitation
Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells. 2016, 7 (1):166 Stem Cell Res TherPublisher
BioMed CentralJournal
Stem cell research & therapyDOI
10.1186/s13287-016-0425-xPubMed ID
27846905Abstract
Cellular reprogramming is a stressful process, which requires cells to engulf somatic features and produce and maintain stemness machineries. Autophagy is a process to degrade unwanted proteins and is required for the derivation of induced pluripotent stem cells (iPSCs). However, the role of autophagy during iPSC maintenance remains undefined.Item Type
ArticleLanguage
enISSN
1757-6512Sponsors
This work was supported by Science Foundation Ireland (SFI), Strategic Research Cluster (SRC), grant numbers SFI: 09/SRCB1794 and 09/SRC/ B1794s1, SFI Investigator Programme 13/IA/1787, SFI TIDA program 14/TIDA/2258, and NUI Galway Grant RSU002ae974a485f413a2113503eed53cd6c53
10.1186/s13287-016-0425-x
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