Show simple item record

dc.contributor.authorMcAnena, Peter F
dc.contributor.authorBrown, James A
dc.contributor.authorRamli, A.
dc.contributor.authorCurran, C.
dc.contributor.authorMalone, C.
dc.contributor.authorMcLaughlin, R.
dc.contributor.authorBarry, K.
dc.contributor.authorJAL, Brown
dc.contributor.authorKerin, M. J
dc.date.accessioned2018-02-28T12:36:51Z
dc.date.available2018-02-28T12:36:51Z
dc.date.issued2018-02-20
dc.identifier.citationBMC Cancer. 2018 Feb 20;18(1):203en
dc.identifier.urihttp://dx.doi.org/10.1186/s12885-018-4101-7
dc.identifier.urihttp://hdl.handle.net/10147/622851
dc.description.abstractAbstract Background Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ultimately prognosis. The aim of the study was to determine the rate of change between primary and recurrence of breast cancer and to assess the impact of these changes on survival and potential treatment options. Methods Patient demographics were collected on those who underwent surgery for breast cancer between 2001 and 2014 and had a recurrence with biopsy results and pathology scoring of both the primary and recurrence. Results One hundred thirty two consecutive patients were included. There were 31 (23.5%) changes in subtype. Discordance occurred most frequently in luminal A breast cancer (n = 20), followed by triple negative (n = 4), luminal B (n = 3) and HER2 (n = 3). Patients who changed from luminal A to triple negative (n = 18) had a significantly worse post-recurrence survival (p < 0.05) with overall survival approaching significance (p = 0.064) compared to concordant luminal A cases (n = 46). Overall receptor discordance rates were: estrogen receptor 20.4% (n = 27), progesterone receptor 37.7% (n = 50) and HER2 3% (n = 4). Loss of estrogen receptor and progesterone receptor was more common than gain (21 vs. 6 (p = 0.04) and 44 vs. 6 (p = 0.01) respectively). Nine patients (6.8%) gained receptor status potentially impacting treatment options. Conclusion Discordance in subtype and receptor status occurs between primary and recurrent breast cancer, ultimately affecting survival and potentially impacting treatment options.
dc.language.isoenen
dc.subjectBREAST CANCERen
dc.subjectTREATMENTen
dc.titleBreast cancer subtype discordance: impact on post-recurrence survival and potential treatment optionsen
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.date.updated2018-02-25T04:17:06Z
refterms.dateFOA2018-08-30T15:27:04Z
html.description.abstractAbstract Background Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ultimately prognosis. The aim of the study was to determine the rate of change between primary and recurrence of breast cancer and to assess the impact of these changes on survival and potential treatment options. Methods Patient demographics were collected on those who underwent surgery for breast cancer between 2001 and 2014 and had a recurrence with biopsy results and pathology scoring of both the primary and recurrence. Results One hundred thirty two consecutive patients were included. There were 31 (23.5%) changes in subtype. Discordance occurred most frequently in luminal A breast cancer (n = 20), followed by triple negative (n = 4), luminal B (n = 3) and HER2 (n = 3). Patients who changed from luminal A to triple negative (n = 18) had a significantly worse post-recurrence survival (p < 0.05) with overall survival approaching significance (p = 0.064) compared to concordant luminal A cases (n = 46). Overall receptor discordance rates were: estrogen receptor 20.4% (n = 27), progesterone receptor 37.7% (n = 50) and HER2 3% (n = 4). Loss of estrogen receptor and progesterone receptor was more common than gain (21 vs. 6 (p = 0.04) and 44 vs. 6 (p = 0.01) respectively). Nine patients (6.8%) gained receptor status potentially impacting treatment options. Conclusion Discordance in subtype and receptor status occurs between primary and recurrent breast cancer, ultimately affecting survival and potentially impacting treatment options.


Files in this item

Thumbnail
Name:
12885_2018_Article_4101.pdf
Size:
650.7Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record