Transfusion-transmitted hepatitis B virus (HBV) infection from an individual-donation nucleic acid (ID-NAT) non-reactive donor.

O'Flaherty, N; Ushiro-Lumb, I; Pomeroy, L; Ijaz, S; Boland, F; De Gascun, C; Fitzgerald, J; O'Riordan, J

dc.contributor.author	O'Flaherty, N
dc.contributor.author	Ushiro-Lumb, I
dc.contributor.author	Pomeroy, L
dc.contributor.author	Ijaz, S
dc.contributor.author	Boland, F
dc.contributor.author	De Gascun, C
dc.contributor.author	Fitzgerald, J
dc.contributor.author	O'Riordan, J
dc.date.accessioned	2018-02-21T15:24:17Z
dc.date.available	2018-02-21T15:24:17Z
dc.date.issued	2018-02-14
dc.identifier.citation	Transfusion-transmitted hepatitis B virus (HBV) infection from an individual-donation nucleic acid (ID-NAT) non-reactive donor. 2018 Vox Sang.	en
dc.identifier.issn	1423-0410
dc.identifier.pmid	29441587
dc.identifier.doi	10.1111/vox.12633
dc.identifier.uri	http://hdl.handle.net/10147/622806
dc.description.abstract	Lookback was initiated upon notification of an acute HBV infection in a repeat Irish donor, 108 days post-donation. The donation screened non-reactive by individual-donation nucleic acid testing (ID-NAT) using the Procleix Ultrio Elite multiplex assay and again when the archived sample was retested, but the discriminatory assay for HBV was reactive. The immunocompromised recipient of the implicated red cell component was tested 110 days post-transfusion, revealing a HBV DNA viral load of 470 IU/ml. Genotype C2 sequences identical across two regions of the HBV genome were found in samples from the donor and recipient.
dc.language.iso	en	en
dc.publisher	Vox sanguinis	en
dc.rights	Archived with thanks to Vox sanguinis	en
dc.title	Transfusion-transmitted hepatitis B virus (HBV) infection from an individual-donation nucleic acid (ID-NAT) non-reactive donor.	en
dc.type	Article	en
dc.identifier.journal	Vox sanguinis	en
refterms.dateFOA	2018-08-28T01:45:02Z
html.description.abstract	Lookback was initiated upon notification of an acute HBV infection in a repeat Irish donor, 108 days post-donation. The donation screened non-reactive by individual-donation nucleic acid testing (ID-NAT) using the Procleix Ultrio Elite multiplex assay and again when the archived sample was retested, but the discriminatory assay for HBV was reactive. The immunocompromised recipient of the implicated red cell component was tested 110 days post-transfusion, revealing a HBV DNA viral load of 470 IU/ml. Genotype C2 sequences identical across two regions of the HBV genome were found in samples from the donor and recipient.