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    Transfusion-transmitted hepatitis B virus (HBV) infection from an individual-donation nucleic acid (ID-NAT) non-reactive donor.

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    Name:
    O'Flaherty_et_al-2018-Vox_Sang ...
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    Authors
    O'Flaherty, N
    Ushiro-Lumb, I
    Pomeroy, L
    Ijaz, S
    Boland, F
    De Gascun, C
    Fitzgerald, J
    O'Riordan, J
    Issue Date
    2018-02-14
    
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    Citation
    Transfusion-transmitted hepatitis B virus (HBV) infection from an individual-donation nucleic acid (ID-NAT) non-reactive donor. 2018 Vox Sang.
    Publisher
    Vox sanguinis
    Journal
    Vox sanguinis
    URI
    http://hdl.handle.net/10147/622806
    DOI
    10.1111/vox.12633
    PubMed ID
    29441587
    Abstract
    Lookback was initiated upon notification of an acute HBV infection in a repeat Irish donor, 108 days post-donation. The donation screened non-reactive by individual-donation nucleic acid testing (ID-NAT) using the Procleix Ultrio Elite multiplex assay and again when the archived sample was retested, but the discriminatory assay for HBV was reactive. The immunocompromised recipient of the implicated red cell component was tested 110 days post-transfusion, revealing a HBV DNA viral load of 470 IU/ml. Genotype C2 sequences identical across two regions of the HBV genome were found in samples from the donor and recipient.
    Item Type
    Article
    Language
    en
    ISSN
    1423-0410
    ae974a485f413a2113503eed53cd6c53
    10.1111/vox.12633
    Scopus Count
    Collections
    Irish Blood Transfusion Service (IBTS)

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