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dc.contributor.authorKennedy, Elizabeth A
dc.contributor.authorConnolly, Jennifer
dc.contributor.authorHourihane, Jonathan O'B
dc.contributor.authorFallon, Padraic G
dc.contributor.authorMcLean, W H Irwin
dc.contributor.authorMurray, Deirdre
dc.contributor.authorJo, Jay-Hyun
dc.contributor.authorSegre, Julia A
dc.contributor.authorKong, Heidi H
dc.contributor.authorIrvine, Alan D
dc.date.accessioned2017-07-31T08:42:43Z
dc.date.available2017-07-31T08:42:43Z
dc.date.issued2017-01
dc.identifier.citationSkin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. 2017, 139 (1):166-172 J. Allergy Clin. Immunol.en
dc.identifier.issn1097-6825
dc.identifier.pmid27609659
dc.identifier.doi10.1016/j.jaci.2016.07.029
dc.identifier.urihttp://hdl.handle.net/10147/621507
dc.descriptionBacterial community structures and diversity shifted over time, suggesting that age strongly affects the skin microbiome in infants. Unlike established AD, these patients with infantile AD did not have noticeably dysbiotic communities before or with disease and were not colonized by S aureus. In comparing patients and control subjects, infants who had affected skin at month 12 had statistically significant differences in bacterial communities on the antecubital fossa at month 2 compared with infants who were unaffected at month 12. In particular, commensal staphylococci were significantly less abundant in infants affected at month 12, suggesting that this genus might protect against the later development of AD.en
dc.description.abstractDisease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition of the skin microbiome between early infancy and the dysbiosis of established AD is unknown.
dc.description.abstractWe randomly selected 50 children from the Cork Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE) longitudinal birth cohort for microbiome sampling at 3 points in the first 6 months of life at 4 skin sites relevant to AD: the antecubital and popliteal fossae, nasal tip, and cheek. We identified 10 infants with AD and compared them with 10 randomly selected control infants with no AD. We performed bacterial 16S ribosomal RNA sequencing and analysis directly from clinical samples.
dc.description.abstractBacterial community structures and diversity shifted over time, suggesting that age strongly affects the skin microbiome in infants. Unlike established AD, these patients with infantile AD did not have noticeably dysbiotic communities before or with disease and were not colonized by S aureus. In comparing patients and control subjects, infants who had affected skin at month 12 had statistically significant differences in bacterial communities on the antecubital fossa at month 2 compared with infants who were unaffected at month 12. In particular, commensal staphylococci were significantly less abundant in infants affected at month 12, suggesting that this genus might protect against the later development of AD.
dc.description.abstractThis study suggests that 12-month-old infants with AD were not colonized with S aureus before having AD. Additional studies are needed to confirm whether colonization with commensal staphylococci modulates skin immunity and attenuates development of AD.
dc.language.isoenen
dc.publisherJournal of Allergy and Clinical Immunologyen
dc.rightsArchived with thanks to The Journal of allergy and clinical immunologyen
dc.subjectMICROBIOLOGYen
dc.subjectDERMATITISen
dc.subject.meshBacteria
dc.subject.meshChild, Preschool
dc.subject.meshDermatitis, Atopic
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshIntermediate Filament Proteins
dc.subject.meshMale
dc.subject.meshMicrobiota
dc.subject.meshRNA, Bacterial
dc.subject.meshRNA, Ribosomal, 16S
dc.subject.meshRisk Factors
dc.subject.meshSkin
dc.titleSkin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year.en
dc.typeArticleen
dc.identifier.journalThe Journal of allergy and clinical immunologyen
refterms.dateFOA2018-08-27T22:44:35Z
html.description.abstractDisease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition of the skin microbiome between early infancy and the dysbiosis of established AD is unknown.
html.description.abstractWe randomly selected 50 children from the Cork Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE) longitudinal birth cohort for microbiome sampling at 3 points in the first 6 months of life at 4 skin sites relevant to AD: the antecubital and popliteal fossae, nasal tip, and cheek. We identified 10 infants with AD and compared them with 10 randomly selected control infants with no AD. We performed bacterial 16S ribosomal RNA sequencing and analysis directly from clinical samples.
html.description.abstractBacterial community structures and diversity shifted over time, suggesting that age strongly affects the skin microbiome in infants. Unlike established AD, these patients with infantile AD did not have noticeably dysbiotic communities before or with disease and were not colonized by S aureus. In comparing patients and control subjects, infants who had affected skin at month 12 had statistically significant differences in bacterial communities on the antecubital fossa at month 2 compared with infants who were unaffected at month 12. In particular, commensal staphylococci were significantly less abundant in infants affected at month 12, suggesting that this genus might protect against the later development of AD.
html.description.abstractThis study suggests that 12-month-old infants with AD were not colonized with S aureus before having AD. Additional studies are needed to confirm whether colonization with commensal staphylococci modulates skin immunity and attenuates development of AD.


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