• Login
    View Item 
    •   Home
    • Irish Health Organisations
    • Publications
    • View Item
    •   Home
    • Irish Health Organisations
    • Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5118
    UlsterS
    5118
    Connacht
    1710
    Munster
    58
    Leinster
    467

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Thumbnail
    Name:
    main.pdf
    Size:
    827.2Kb
    Format:
    PDF
    Description:
    Main Article
    Download
    Authors
    Kennedy, Elizabeth A
    Connolly, Jennifer
    Hourihane, Jonathan O'B
    Fallon, Padraic G
    McLean, W H Irwin
    Murray, Deirdre
    Jo, Jay-Hyun
    Segre, Julia A
    Kong, Heidi H
    Irvine, Alan D
    Issue Date
    2017-01
    Keywords
    MICROBIOLOGY
    DERMATITIS
    MeSH
    Bacteria
    Child, Preschool
    Dermatitis, Atopic
    Female
    Humans
    Infant
    Intermediate Filament Proteins
    Male
    Microbiota
    RNA, Bacterial
    RNA, Ribosomal, 16S
    Risk Factors
    Skin
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. 2017, 139 (1):166-172 J. Allergy Clin. Immunol.
    Publisher
    Journal of Allergy and Clinical Immunology
    Journal
    The Journal of allergy and clinical immunology
    URI
    http://hdl.handle.net/10147/621507
    DOI
    10.1016/j.jaci.2016.07.029
    PubMed ID
    27609659
    Abstract
    Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition of the skin microbiome between early infancy and the dysbiosis of established AD is unknown.
    We randomly selected 50 children from the Cork Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE) longitudinal birth cohort for microbiome sampling at 3 points in the first 6 months of life at 4 skin sites relevant to AD: the antecubital and popliteal fossae, nasal tip, and cheek. We identified 10 infants with AD and compared them with 10 randomly selected control infants with no AD. We performed bacterial 16S ribosomal RNA sequencing and analysis directly from clinical samples.
    Bacterial community structures and diversity shifted over time, suggesting that age strongly affects the skin microbiome in infants. Unlike established AD, these patients with infantile AD did not have noticeably dysbiotic communities before or with disease and were not colonized by S aureus. In comparing patients and control subjects, infants who had affected skin at month 12 had statistically significant differences in bacterial communities on the antecubital fossa at month 2 compared with infants who were unaffected at month 12. In particular, commensal staphylococci were significantly less abundant in infants affected at month 12, suggesting that this genus might protect against the later development of AD.
    This study suggests that 12-month-old infants with AD were not colonized with S aureus before having AD. Additional studies are needed to confirm whether colonization with commensal staphylococci modulates skin immunity and attenuates development of AD.
    Item Type
    Article
    Language
    en
    ISSN
    1097-6825
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jaci.2016.07.029
    Scopus Count
    Collections
    Publications

    entitlement

    Related articles

    • Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis.
    • Authors: Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, Nomicos E, Polley EC, Komarow HD, NISC Comparative Sequence Program, Murray PR, Turner ML, Segre JA
    • Issue date: 2012 May
    • Skin dysbiosis in the microbiome in atopic dermatitis is site-specific and involves bacteria, fungus and virus.
    • Authors: Bjerre RD, Holm JB, Palleja A, Sølberg J, Skov L, Johansen JD
    • Issue date: 2021 Sep 23
    • Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review.
    • Authors: Demessant-Flavigny AL, Connétable S, Kerob D, Moreau M, Aguilar L, Wollenberg A
    • Issue date: 2023 Jun
    • Skin Microbiome in Atopic Dermatitis.
    • Authors: Edslev SM, Agner T, Andersen PS
    • Issue date: 2020 Jun 9
    • Dysbiosis of skin microbiota with increased fungal diversity is associated with severity of disease in atopic dermatitis.
    • Authors: Schmid B, Künstner A, Fähnrich A, Bersuch E, Schmid-Grendelmeier P, Busch H, Glatz M, Bosshard PP
    • Issue date: 2022 Oct
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.