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dc.contributor.authorHennebry, Jennifer*
dc.contributor.authorMulholland, Douglas*
dc.contributor.authorTchrakian, Nairi*
dc.contributor.authorMartin Gillham, Charles*
dc.contributor.authorJulian Beddy, Peter*
dc.contributor.authorMai O'Donnell, Dearbhaile*
dc.contributor.authorEibhlín McMenamin, Máirín*
dc.date.accessioned2017-05-29T15:18:52Z
dc.date.available2017-05-29T15:18:52Z
dc.date.issued2017-01
dc.identifier.citationNodular fasciitis: A pseudomalignant clonal neoplasm characterized by USP gene rearrangements and spontaneous regression 2017, 8 (01):80 International Journal of Case Reports and Imagesen
dc.identifier.issn0976-3198
dc.identifier.doi10.5348/ijcri-201713-CR-10752
dc.identifier.urihttp://hdl.handle.net/10147/621403
dc.description.abstractIntroduction: Nodular fasciitis (NF) is a rapidly growing, self-limited, myofibroblastic neoplasm that typically arises in subcutaneous tissues of young adults and regresses spontaneously. Nodular fasciitis mimics sarcoma on clinical, radiological, and histological grounds and is usually, diagnosed following excision. Case Report: A 26-year-old female presented at surveillance computed tomography (CT) scan one year post-treatment for stage 1c ovarian dysgerminoma with a 4 cm axillary soft tissue mass, radiologically suspicious for metastasis with subclavian vein invasion. Histopathology of core biopsies favored NF, confirmed by detection of USP6 gene rearrangements by FISH analysis. This case describes an unusual relatively deep NF, suspicious for metastasis on CT scan with confirmed spontaneous regression over two years. Conclusion: Nodular fasciitis should be considered in the differential diagnosis of rapidly growing enhancing soft tissue masses. Molecular cytogenetic testing of USP6 gene rearrangements allows definitive diagnosis on core biopsies in challenging cases, permitting a conservative approach and avoiding potentially radical and unnecessary surgery.
dc.language.isoenen
dc.publisherEdorium Journalsen
dc.relation.urlhttp://www.ijcasereportsandimages.com/archive/2017/001-2017-ijcri/CR-10752-01-2017-hennebry/ijcri-1075201201752-hennebry-full-text.phpen
dc.rightsArchived with thanks to International Journal of Case Reports and Imagesen
dc.subjectNEOPLASMSen
dc.subjectNODULAR FACIITISen
dc.titleNodular fasciitis: A pseudomalignant clonal neoplasm characterized by USP gene rearrangements and spontaneous regressionen
dc.typeArticleen
dc.identifier.journalInternational Journal of Case Reports and Imagesen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
refterms.dateFOA2018-08-27T21:27:34Z
html.description.abstractIntroduction: Nodular fasciitis (NF) is a rapidly growing, self-limited, myofibroblastic neoplasm that typically arises in subcutaneous tissues of young adults and regresses spontaneously. Nodular fasciitis mimics sarcoma on clinical, radiological, and histological grounds and is usually, diagnosed following excision. Case Report: A 26-year-old female presented at surveillance computed tomography (CT) scan one year post-treatment for stage 1c ovarian dysgerminoma with a 4 cm axillary soft tissue mass, radiologically suspicious for metastasis with subclavian vein invasion. Histopathology of core biopsies favored NF, confirmed by detection of USP6 gene rearrangements by FISH analysis. This case describes an unusual relatively deep NF, suspicious for metastasis on CT scan with confirmed spontaneous regression over two years. Conclusion: Nodular fasciitis should be considered in the differential diagnosis of rapidly growing enhancing soft tissue masses. Molecular cytogenetic testing of USP6 gene rearrangements allows definitive diagnosis on core biopsies in challenging cases, permitting a conservative approach and avoiding potentially radical and unnecessary surgery.


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