• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • St. Luke's Radiation Oncology Network, Dublin
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • St. Luke's Radiation Oncology Network, Dublin
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4378
    UlsterS
    4378
    Connacht
    1408
    Munster
    62
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideHSE Library Guide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Increased mitochondrial mass in cells with functionally compromised mitochondria after exposure to both direct gamma radiation and bystander factors.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Increased Mitochondrial Mass in ...
    Size:
    841.1Kb
    Format:
    PDF
    Download
    Authors
    Nugent, Sharon M E
    Mothersill, Carmel E
    Seymour, Colin
    McClean, Brendan
    Lyng, Fiona M
    Murphy, James E J
    Issue Date
    2007-07
    Keywords
    RADIOTHERAPY
    RADIATION
    MeSH
    Animals
    Bystander Effect
    Cell Line
    Cricetinae
    Gamma Rays
    Humans
    Mitochondria
    Mitochondrial Size
    Oxygen
    
    Metadata
    Show full item record
    Citation
    Increased mitochondrial mass in cells with functionally compromised mitochondria after exposure to both direct gamma radiation and bystander factors. 2007, 168 (1):134-42 Radiat. Res.
    Journal
    Radiation research
    URI
    http://hdl.handle.net/10147/621398
    DOI
    10.1667/RR0769.1
    PubMed ID
    17722997
    Abstract
    The bystander effect describes radiation-like damage in unirradiated cells either in the vicinity of irradiated cells or exposed to medium from irradiated cells. This study aimed to further characterize the poorly understood mitochondrial response to both direct irradiation and bystander factor(s) in human keratinocytes (HPV-G) and Chinese hamster ovarian cells (CHO-K1). Oxygen consumption rates were determined during periods of state 4, state 3 and uncoupled respiration. Mitochondrial mass was determined using MitoTracker FM. CHO-K1 cells showed significantly reduced oxygen consumption rates 4 h after exposure to 5 Gy direct radiation and irradiated cell conditioned medium (ICCM) and an apparent recovery 12-24 h later. The apparent recovery was likely due to the substantial increase in mitochondrial mass observed in these cells as soon as 4 h after exposure. HPV-G cells, on the other hand, showed a sustained increase in oxygen consumption rates after ICCM exposure and a transient increase 4 h after exposure to 5 Gy direct radiation. A significant increase in mitochondrial mass per HPV-G cell was observed after exposure to both direct radiation and ICCM. These findings are indicative of a stress response to mitochondrial dysfunction that increases the number of mitochondria per cell.
    Item Type
    Article
    Language
    en
    ISSN
    0033-7587
    ae974a485f413a2113503eed53cd6c53
    10.1667/RR0769.1
    Scopus Count
    Collections
    St. Luke's Radiation Oncology Network, Dublin

    entitlement

    Related articles

    • Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells.
    • Authors: Murphy JE, Nugent S, Seymour C, Mothersill C
    • Issue date: 2005 Aug 1
    • Altered mitochondrial function and genome frequency post exposure to γ-radiation and bystander factors.
    • Authors: Nugent S, Mothersill CE, Seymour C, McClean B, Lyng FM, Murphy JE
    • Issue date: 2010 Oct
    • Modulation of radiation responses by pre-exposure to irradiated cell conditioned medium.
    • Authors: Maguire P, Mothersill C, McClean B, Seymour C, Lyng FM
    • Issue date: 2007 Apr
    • Comparison of direct and bystander effects induced by ionizing radiation in eight fish cell lines.
    • Authors: O'Neill-Mehlenbacher A, Kilemade M, Elliott A, Mothersill C, Seymour C
    • Issue date: 2007 Sep
    • Dilution of irradiated cell conditioned medium and the bystander effect.
    • Authors: Ryan LA, Smith RW, Seymour CB, Mothersill CE
    • Issue date: 2008 Feb
    HSE Library | Health Service Executive | Dr Steevens’ Hospital, Dublin 8 | Republic of Ireland | Eircode: D08 W2A8
    lenus@hse.ie
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.