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    Modulation of Radiation responses by pre-exposure to irradiated Cell conditioned medium.

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    Authors
    Maguire, Paula
    Mothersill, Carmel
    McClean, Brendan
    Seymour, Colin
    Lyng, Fiona M
    Issue Date
    2007-04
    Keywords
    HUMAN PAPILLOMA VIRUS
    NEOPLASMS
    CANCER
    RADIOTHERAPY
    MeSH
    Adaptation, Physiological
    Cell Line
    Cell Survival
    Culture Media, Conditioned
    DNA
    DNA Damage
    Dose-Response Relationship, Radiation
    Humans
    Keratinocytes
    Radiation Dosage
    Radiation Tolerance
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    Citation
    Modulation of radiation responses by pre-exposure to irradiated cell conditioned medium. 2007, 167 (4):485-92 Radiat. Res.
    Publisher
    Radiation Research Society
    Journal
    Radiation research
    URI
    http://hdl.handle.net/10147/621394
    DOI
    10.1667/RR0159.1
    PubMed ID
    17388689
    Abstract
    The aim of this study was to investigate whether exposure of HPV-G cells to irradiated cell conditioned medium (ICCM) could induce an adaptive response if the cells were subsequently challenged with a higher ICCM dose. Clonogenic survival and major steps in the cascade leading to apoptosis, such as calcium influx and loss of mitochondrial membrane potential, were examined to determine whether these events could be modified by giving a priming dose of ICCM before the challenge dose. Clonogenic survival data indicated an ICCM-induced adaptive response in HPV-G cells "primed" with 5 mGy or 0.5 Gy ICCM for 24 h and then exposed to 0.5 Gy or 5 Gy ICCM. Reactive oxygen species (ROS) were found to be involved in the bystander-induced cell death. Calcium fluxes varied in magnitude across the exposed cell population, and a significant number of the primed HPV-G cells did not respond to the challenge ICCM dose. No significant loss of mitochondrial membrane potential was observed when HPV-G cells were exposed to 0.5 Gy ICCM for 24 h followed by exposure to 5 Gy ICCM for 6 h. Exposure of HPV-G cells to 5 mGy ICCM for 24 h followed by exposure to 0.5 Gy ICCM for 18 h caused a significant increase in mitochondrial mass and a change in mitochondrial location, events associated with the perpetuation of genomic instability. This study has shown that a priming dose of ICCM has the ability to induce an adaptive response in HPV-G cells subsequently exposed to a challenge dose of ICCM.
    Item Type
    Article
    Language
    en
    ISSN
    0033-7587
    ae974a485f413a2113503eed53cd6c53
    10.1667/RR0159.1
    Scopus Count
    Collections
    St. Luke's Radiation Oncology Network, Dublin

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