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    The Role of Proteomics in Biomarker Development for Improved Patient Diagnosis and Clinical Decision Making in Prostate Cancer.

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    Authors
    Tonry, Claire L
    Leacy, Emma
    Raso, Cinzia
    Finn, Stephen P
    Armstrong, John
    Pennington, Stephen R
    Issue Date
    2016-07-18
    Keywords
    PROSTATE CANCER
    PROTEOMICS
    BIOMARKERS
    
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    Citation
    The Role of Proteomics in Biomarker Development for Improved Patient Diagnosis and Clinical Decision Making in Prostate Cancer. 2016, 6 (3) Diagnostics (Basel)
    Journal
    Diagnostics (Basel, Switzerland)
    URI
    http://hdl.handle.net/10147/621272
    DOI
    10.3390/diagnostics6030027
    PubMed ID
    27438858
    Additional Links
    http://www.mdpi.com/2075-4418/6/3/27/htm
    Abstract
    Prostate Cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. Although increased expression of prostate-specific antigen (PSA) is an effective indicator for the recurrence of PCa, its intended use as a screening marker for PCa is of considerable controversy. Recent research efforts in the field of PCa biomarkers have focused on the identification of tissue and fluid-based biomarkers that would be better able to stratify those individuals diagnosed with PCa who (i) might best receive no treatment (active surveillance of the disease); (ii) would benefit from existing treatments; or (iii) those who are likely to succumb to disease recurrence and/or have aggressive disease. The growing demand for better prostate cancer biomarkers has coincided with the development of improved discovery and evaluation technologies for multiplexed measurement of proteins in bio-fluids and tissues. This review aims to (i) provide an overview of these technologies as well as describe some of the candidate PCa protein biomarkers that have been discovered using them; (ii) address some of the general limitations in the clinical evaluation and validation of protein biomarkers; and (iii) make recommendations for strategies that could be adopted to improve the successful development of protein biomarkers to deliver improvements in personalized PCa patient decision making.
    Item Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/diagnostics6030027
    Scopus Count
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    St. Luke's Radiation Oncology Network, Dublin

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