The Role of Proteomics in Biomarker Development for Improved Patient Diagnosis and Clinical Decision Making in Prostate Cancer.
Citation
The Role of Proteomics in Biomarker Development for Improved Patient Diagnosis and Clinical Decision Making in Prostate Cancer. 2016, 6 (3) Diagnostics (Basel)Journal
Diagnostics (Basel, Switzerland)DOI
10.3390/diagnostics6030027PubMed ID
27438858Additional Links
http://www.mdpi.com/2075-4418/6/3/27/htmAbstract
Prostate Cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. Although increased expression of prostate-specific antigen (PSA) is an effective indicator for the recurrence of PCa, its intended use as a screening marker for PCa is of considerable controversy. Recent research efforts in the field of PCa biomarkers have focused on the identification of tissue and fluid-based biomarkers that would be better able to stratify those individuals diagnosed with PCa who (i) might best receive no treatment (active surveillance of the disease); (ii) would benefit from existing treatments; or (iii) those who are likely to succumb to disease recurrence and/or have aggressive disease. The growing demand for better prostate cancer biomarkers has coincided with the development of improved discovery and evaluation technologies for multiplexed measurement of proteins in bio-fluids and tissues. This review aims to (i) provide an overview of these technologies as well as describe some of the candidate PCa protein biomarkers that have been discovered using them; (ii) address some of the general limitations in the clinical evaluation and validation of protein biomarkers; and (iii) make recommendations for strategies that could be adopted to improve the successful development of protein biomarkers to deliver improvements in personalized PCa patient decision making.Item Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.3390/diagnostics6030027
Scopus Count
Collections
Related articles
- Proteomics in diagnosis of prostate cancer.
- Authors: Davalieva K, Polenakovic M
- Issue date: 2015
- Genomic Markers in Prostate Cancer Decision Making.
- Authors: Cucchiara V, Cooperberg MR, Dall'Era M, Lin DW, Montorsi F, Schalken JA, Evans CP
- Issue date: 2018 Apr
- More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
- Authors: Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
- Issue date: 2019 Jan-Apr
- The role of proteomics in prostate cancer research: biomarker discovery and validation.
- Authors: Pin E, Fredolini C, Petricoin EF 3rd
- Issue date: 2013 Apr
- Clinical proteomics for prostate cancer: understanding prostate cancer pathology and protein biomarkers for improved disease management.
- Authors: Tonry C, Finn S, Armstrong J, Pennington SR
- Issue date: 2020 Nov 20