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    Targeting the Pim kinases in multiple myeloma.

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    TargetingPimKinasesMultipleMye ...
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    Authors
    Keane, N A
    Reidy, M
    Natoni, A
    Raab, M S
    O'Dwyer, M
    Issue Date
    2015-07-17
    Keywords
    CANCER
    MULTIPLE MYELOMA
    MeSH
    Animals
    Antineoplastic Agents
    Cell Proliferation
    Drug Resistance, Neoplasm
    Gene Expression Regulation, Neoplastic
    Humans
    Molecular Targeted Therapy
    Multiple Myeloma
    Protein Kinase Inhibitors
    Proto-Oncogene Proteins c-pim-1
    Signal Transduction
    Up-Regulation
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    Citation
    Targeting the Pim kinases in multiple myeloma. 2015, 5:e325 Blood Cancer J
    Publisher
    Nature Publishing Group
    Journal
    Blood cancer journal
    URI
    http://hdl.handle.net/10147/621140
    DOI
    10.1038/bcj.2015.46
    PubMed ID
    26186558
    Abstract
    Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. Novel treatment strategies to improve survival are urgently required. The Pims are a small family of serine/threonine kinases with increased expression across the hematological malignancies. Pim-2 shows highest expression in MM and constitutes a promising therapeutic target. It is upregulated by the bone marrow microenvironment to mediate proliferation and promote MM survival. Pim-2 also has a key role in the bone destruction typically seen in MM. Additional putative roles of the Pim kinases in MM include trafficking of malignant cells, promoting oncogenic signaling in the hypoxic bone marrow microenvironment and mediating resistance to therapy. A number of Pim inhibitors are now under development with lead compounds entering the clinic. The ATP-competitive Pim inhibitor LGH447 has recently been reported to have single agent activity in MM. It is anticipated that Pim inhibition will be of clinical benefit in combination with standard treatments and/or with novel drugs targeting other survival pathways in MM.
    Item Type
    Article
    Language
    en
    ISSN
    2044-5385
    ae974a485f413a2113503eed53cd6c53
    10.1038/bcj.2015.46
    Scopus Count
    Collections
    Galway University Hospitals

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