Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.
Cell Line, Tumor
Platelet Aggregation Inhibitors
Purinergic P2Y Receptor Antagonists
Real-Time Polymerase Chain Reaction
Receptors, Purinergic P2Y12
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CitationAspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion. 2015, 15:627 BMC Cancer
AbstractPlatelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian cancers have different metastatic phenotypes. To investigate if platelet-cancer cell interactions play a role, we characterized the response of ovarian cancer cell lines to platelets both functionally and at a molecular level.