Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.

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Authors
Cooke, Niamh M
Spillane, Cathy D
Sheils, Orla
O'Leary, John
Kenny, Dermot
Issue Date
2015-09-09
Keywords
OVARIAN CANCER
MeSH
Adenosine Monophosphate
Aspirin
Blood Platelets
Cell Line, Tumor
Female
Flow Cytometry
Humans
Neoplasm Invasiveness
Neoplasm Metastasis
Ovarian Neoplasms
Platelet Aggregation Inhibitors
Purinergic P2Y Receptor Antagonists
Real-Time Polymerase Chain Reaction
Receptors, Purinergic P2Y12

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Citation
Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion. 2015, 15:627 BMC Cancer
Publisher
BioMed Central
Journal
BMC cancer
URI
http://hdl.handle.net/10147/621134
DOI
10.1186/s12885-015-1634-x
PubMed ID
26353776
Abstract
Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian cancers have different metastatic phenotypes. To investigate if platelet-cancer cell interactions play a role, we characterized the response of ovarian cancer cell lines to platelets both functionally and at a molecular level.
Item Type
Article
Language
en
ISSN
1471-2407
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