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    Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.

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    Authors
    Cooke, Niamh M
    Spillane, Cathy D
    Sheils, Orla
    O'Leary, John
    Kenny, Dermot
    Issue Date
    2015-09-09
    Keywords
    OVARIAN CANCER
    MeSH
    Adenosine Monophosphate
    Aspirin
    Blood Platelets
    Cell Line, Tumor
    Female
    Flow Cytometry
    Humans
    Neoplasm Invasiveness
    Neoplasm Metastasis
    Ovarian Neoplasms
    Platelet Aggregation Inhibitors
    Purinergic P2Y Receptor Antagonists
    Real-Time Polymerase Chain Reaction
    Receptors, Purinergic P2Y12
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    Citation
    Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion. 2015, 15:627 BMC Cancer
    Publisher
    BioMed Central
    Journal
    BMC cancer
    URI
    http://hdl.handle.net/10147/621134
    DOI
    10.1186/s12885-015-1634-x
    PubMed ID
    26353776
    Abstract
    Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian cancers have different metastatic phenotypes. To investigate if platelet-cancer cell interactions play a role, we characterized the response of ovarian cancer cell lines to platelets both functionally and at a molecular level.
    Item Type
    Article
    Language
    en
    ISSN
    1471-2407
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12885-015-1634-x
    Scopus Count
    Collections
    Coombe Women & Infants University Hospital

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