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    Potentially inappropriate prescribing in two populations with differing socio-economic profiles: a cross-sectional database study using the PROMPT criteria.

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    Authors
    Cooper, Janine A
    Moriarty, Frank
    Ryan, Cristín
    Smith, Susan M
    Bennett, Kathleen
    Fahey, Tom
    Wallace, Emma
    Cahir, Caitriona
    Williams, David
    Teeling, Mary
    Hughes, Carmel M
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    Issue Date
    2016-01-28
    Keywords
    PRESCRIBING
    
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    Citation
    Potentially inappropriate prescribing in two populations with differing socio-economic profiles: a cross-sectional database study using the PROMPT criteria. 2016: Eur. J. Clin. Pharmacol.
    Publisher
    Springer
    Journal
    European journal of clinical pharmacology
    URI
    http://hdl.handle.net/10147/620778
    DOI
    10.1007/s00228-015-2003-z
    PubMed ID
    26820292
    Abstract
    The purpose of this study is to establish the prevalence of potentially inappropriate prescribing (PIP) in middle-aged adults (45-64 years) in two populations with differing socio-economic profiles, and to investigate factors associated with PIP, using the PROMPT (PRescribing Optimally in Middle-aged People's Treatments) criteria.
    A retrospective cross-sectional study was conducted using 2012 data from the Enhanced Prescribing Database (EPD), covering the full population in Northern Ireland and the Health Services Executive Primary Care Reimbursement Service (HSE-PCRS) database, covering the most socio-economically deprived third of the population in this age group in the Republic of Ireland. The prevalence for each PROMPT criterion and overall prevalence of PIP were calculated. Logistic regression was used to investigate the association between PIP and gender, age group and polypharmacy.
    This study included 441,925 patients from the EPD and 309,748 patients from the HSE-PCRS database. Polypharmacy was common in both datasets (46.7 % in the HSE-PCRS and 20.3 % in the EPD). The prevalence of PIP was 42.9 % (95%CI 42.7, 43.1) in the HSE-PCRS and 21.1 % (95%CI 21.0, 21.2) in the EPD. Age group, female gender and polypharmacy were significantly associated with PIP in both populations (p < 0.05) and polypharmacy had the strongest association.
    PIP is common amongst middle-aged people with the risk of PIP increasing with polypharmacy. Differences in the prevalence of polypharmacy and PIP between the two populations may relate to heterogeneity in healthcare services and different socio-economic profiles, with higher rates of multimorbidity and associated polypharmacy in more deprived groups.
    Item Type
    Article
    Language
    en
    ISSN
    1432-1041
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00228-015-2003-z
    Scopus Count
    Collections
    Royal College of Surgeons in Ireland (RCSI)

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