Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.

Johnson, Nichola; Dudbridge, Frank; Orr, Nick; Gibson, Lorna; Jones, Michael E; Schoemaker, Minouk J; Folkerd, Elizabeth J; Haynes, Ben P; Hopper, John L; Southey, Melissa C; Dite, Gillian S; Apicella, Carmel; Schmidt, Marjanka K; Broeks, Annegien; Van't Veer, Laura J; Atsma, Femke; Muir, Kenneth; Lophatananon, Artitaya; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Renner, Stefan P; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Miller, Nicola; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Guénel, Pascal; Truong, Therese; Cordina, Emilie; Menegaux, Florence; Bojesen, Stig E; Nordestgaard, Børge G; Flyger, Henrik; Milne, Roger; Zamora, M Pilar; Arias Perez, Jose Ignacio; Benitez, Javier; Bernstein, Leslie; Anton-Culver, Hoda; Ziogas, Argyrios; Clarke Dur, Christina; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Dieffenbach, Aida Karina; Meindl, Alfons; Heil, Joerg; Bartram, Claus R; Schmutzler, Rita K; Brauch, Hiltrud; Justenhoven, Christina; Ko, Yon-Dschun; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Matsuo, Keitaro; Dörk, Thilo; Bogdanova, Natalia V; Antonenkova, Natalia N; Lindblom, Annika; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Chenevix-Trench, Georgia; Beesley, Jonathan; Wu, Anna H; Van den Berg, David; Tseng, Chiu-Chen; Lambrechts, Diether; Smeets, Dominiek; Neven, Patrick; Wildiers, Hans; Chang-Claude, Jenny; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Pensotti, Valeria; Couch, Fergus J; Olson, Janet E; Wang, Xianshu; Fredericksen, Zachary; Pankratz, Vernon S; Giles, Graham G; Severi, Gianluca; Baglietto, Laura; Haiman, Chris; Simard, Jacques; Goldberg, Mark S; Labrèche, France; Dumont, Martine; Soucy, Penny; Teo, Soo; Yip, Cheng Har; Phuah, Sze Yee; Cornes, Belinda K; Kristensen, Vessela N; Grenaker Alnæs, Grethe; Børresen-Dale, Anne-Lise; Zheng, Wei; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Devillee, Peter; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Sherman, Mark E; Hall, Per; Schoof, Nils; Hooning, Maartje; Hollestelle, Antoinette; Oldenburg, Rogier A; Tilanus-Linthorst, Madeleine; Liu, Jianjun; Cox, Angie; Brock, Ian W; Reed, Malcolm W R; Cross, Simon S; Blot, William; Signorello, Lisa B; Pharoah, Paul D P; Dunning, Alison M; Shah, Mitul; Kang, Daehee; Noh, Dong-Young; Park, Sue K; Choi, Ji-Yeob; Hartman, Mikael; Miao, Hui; Lim, Wei Yen; Tang, Anthony; Hamann, Ute; Försti, Asta; Rüdiger, Thomas; Ulmer, Hans Ulrich; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Slager, Susan; Toland, Amanda E; Vachon, Celine; Yannoukakos, Drakoulis; Shen, Chen-Yang; Yu, Jyh-Cherng; Huang, Chiun-Sheng; Hou, Ming-Feng; González-Neira, Anna; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Dennis, Joe; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Jean; Easton, Douglas F; García-Closas, Montserrat; Dowsett, Mitch; Ashworth, Alan; Swerdlow, Anthony J; Peto, Julian; dos Santos Silva, Isabel; Fletcher, Olivia

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Authors

Johnson, Nichola
Dudbridge, Frank
Orr, Nick
Gibson, Lorna
Jones, Michael E
Schoemaker, Minouk J
Folkerd, Elizabeth J
Haynes, Ben P
Hopper, John L
Southey, Melissa C
Dite, Gillian S
Apicella, Carmel
Schmidt, Marjanka K
Broeks, Annegien
Van't Veer, Laura J
Atsma, Femke
Muir, Kenneth
Lophatananon, Artitaya
Fasching, Peter A
Beckmann, Matthias W
Ekici, Arif B
Renner, Stefan P
Sawyer, Elinor
Tomlinson, Ian
Kerin, Michael
Miller, Nicola
Burwinkel, Barbara
Marme, Frederik
Schneeweiss, Andreas
Sohn, Christof
Guénel, Pascal
Truong, Therese
Cordina, Emilie
Menegaux, Florence
Bojesen, Stig E
Nordestgaard, Børge G
Flyger, Henrik
Milne, Roger
Zamora, M Pilar
Arias Perez, Jose Ignacio
Benitez, Javier
Bernstein, Leslie
Anton-Culver, Hoda
Ziogas, Argyrios
Clarke Dur, Christina
Brenner, Hermann
Müller, Heiko
Arndt, Volker
Dieffenbach, Aida Karina
Meindl, Alfons
Heil, Joerg
Bartram, Claus R
Schmutzler, Rita K
Brauch, Hiltrud
Justenhoven, Christina
Ko, Yon-Dschun
Nevanlinna, Heli
Muranen, Taru A
Aittomäki, Kristiina
Blomqvist, Carl
Matsuo, Keitaro
Dörk, Thilo
Bogdanova, Natalia V
Antonenkova, Natalia N
Lindblom, Annika
Mannermaa, Arto
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Chenevix-Trench, Georgia
Beesley, Jonathan
Wu, Anna H
Van den Berg, David
Tseng, Chiu-Chen
Lambrechts, Diether
Smeets, Dominiek
Neven, Patrick
Wildiers, Hans
Chang-Claude, Jenny
Rudolph, Anja
Nickels, Stefan
Flesch-Janys, Dieter
Radice, Paolo
Peterlongo, Paolo
Bonanni, Bernardo
Pensotti, Valeria
Couch, Fergus J
Olson, Janet E
Wang, Xianshu
Fredericksen, Zachary
Pankratz, Vernon S
Giles, Graham G
Severi, Gianluca
Baglietto, Laura
Haiman, Chris
Simard, Jacques
Goldberg, Mark S
Labrèche, France
Dumont, Martine
Soucy, Penny
Teo, Soo
Yip, Cheng Har
Phuah, Sze Yee
Cornes, Belinda K
Kristensen, Vessela N
Grenaker Alnæs, Grethe
Børresen-Dale, Anne-Lise
Zheng, Wei
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Andrulis, Irene L
Knight, Julia A
Glendon, Gord
Mulligan, Anna Marie
Devillee, Peter
Figueroa, Jonine
Chanock, Stephen J
Lissowska, Jolanta
Sherman, Mark E
Hall, Per
Schoof, Nils
Hooning, Maartje
Hollestelle, Antoinette
Oldenburg, Rogier A
Tilanus-Linthorst, Madeleine
Liu, Jianjun
Cox, Angie
Brock, Ian W
Reed, Malcolm W R
Cross, Simon S
Blot, William
Signorello, Lisa B
Pharoah, Paul D P
Dunning, Alison M
Shah, Mitul
Kang, Daehee
Noh, Dong-Young
Park, Sue K
Choi, Ji-Yeob
Hartman, Mikael
Miao, Hui
Lim, Wei Yen
Tang, Anthony
Hamann, Ute
Försti, Asta
Rüdiger, Thomas
Ulmer, Hans Ulrich
Jakubowska, Anna
Lubinski, Jan
Jaworska-Bieniek, Katarzyna
Durda, Katarzyna
Sangrajrang, Suleeporn
Gaborieau, Valerie
Brennan, Paul
McKay, James
Slager, Susan
Toland, Amanda E
Vachon, Celine
Yannoukakos, Drakoulis
Shen, Chen-Yang
Yu, Jyh-Cherng
Huang, Chiun-Sheng
Hou, Ming-Feng
González-Neira, Anna
Tessier, Daniel C
Vincent, Daniel
Bacot, Francois
Luccarini, Craig
Dennis, Joe
Michailidou, Kyriaki
Bolla, Manjeet K
Wang, Jean
Easton, Douglas F
García-Closas, Montserrat
Dowsett, Mitch
Ashworth, Alan
Swerdlow, Anthony J
Peto, Julian
dos Santos Silva, Isabel
Fletcher, Olivia

Issue Date

2014-05-26

Keywords

BREAST CANCER

MeSH

Adult
Age Factors
Age of Onset
Aged
Breast Neoplasms
Cytochrome P-450 CYP3A
European Continental Ancestry Group
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Menarche
Middle Aged
Polymorphism, Single Nucleotide
Premenopause
Reproductive History
Risk Factors

Metadata

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Citation

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study. 2014, 16 (3):R51 Breast Cancer Res.

Publisher

BioMed Central

Journal

Breast cancer research : BCR

URI

http://hdl.handle.net/10147/620767

DOI

10.1186/bcr3662

PubMed ID

24887515

Additional Links

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522594/
http://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3662

Abstract

We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.

Item Type

Article

Language

ISSN

1465-542X

Collections

Galway University Hospitals