LC3B globular structures correlate with survival in esophageal adenocarcinoma.
O'Donovan, Tracey R
Kay, Elaine W
Abdallah, Ayat R
O'Sullivan, Gerald C
McKenna, Sharon L
Cell Line, Tumor
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CitationLC3B globular structures correlate with survival in esophageal adenocarcinoma. 2015, 15:582 BMC Cancer
AbstractEsophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome.
SponsorsThis work was funded by the Egyptian Education Bureau. We are also grateful to the Higher Education Authority of Ireland and Breakthrough Cancer Research for financial support.