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    Effects of ZNF804A on auditory P300 response in schizophrenia.

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    OA Article
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    Authors
    O'Donoghue, T
    Morris, D W
    Fahey, C
    Da Costa, A
    Moore, S
    Cummings, E
    Leicht, G
    Karch, S
    Hoerold, D
    Tropea, D
    Foxe, J J
    Gill, M
    Corvin, A
    Donohoe, G
    Show allShow less
    Issue Date
    2014-01
    Keywords
    SCHIZOPHRENIA
    GENETICS
    MeSH
    Adult
    Electroencephalography
    Endophenotypes
    Event-Related Potentials, P300
    Evoked Potentials, Auditory
    Female
    Genotype
    Humans
    Kruppel-Like Transcription Factors
    Male
    Middle Aged
    Polymorphism, Single Nucleotide
    Schizophrenia
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    Metadata
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    Citation
    Effects of ZNF804A on auditory P300 response in schizophrenia. 2014, 4:e345 Transl Psychiatry
    Publisher
    Nature Publishing Group
    Journal
    Translational psychiatry
    URI
    http://hdl.handle.net/10147/567069
    DOI
    10.1038/tp.2013.115
    PubMed ID
    24424391
    Additional Links
    http://www.nature.com/tp/journal/v4/n1/full/tp2013115a.html
    Abstract
    The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. Although associated with a pattern of altered neural connectivity, evidence that increased risk is mediated by an effect on cognitive deficits associated with the disorder has been equivocal. This study investigated whether the same ZNF804A risk allele was associated with variation in the P300 auditory-evoked response, a cognitively relevant putative endophenotype for SZ. We compared P300 responses in carriers and noncarriers of the ZNF804A risk allele genotype groups in Irish patients and controls (n=97). P300 response was observed to vary according to genotype in this sample, such that risk allele carriers showed relatively higher P300 response compared with noncarriers. This finding accords with behavioural data reported by our group and others. It is also consistent with the idea that ZNF804A may have an impact on cortical efficiency, reflected in the higher levels of activations required to achieve comparable behavioural accuracy on the task used.
    Item Type
    Article
    Language
    en
    ISSN
    2158-3188
    ae974a485f413a2113503eed53cd6c53
    10.1038/tp.2013.115
    Scopus Count
    Collections
    St. James's Hospital

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