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dc.contributor.authorLennon, Gráinne
dc.contributor.authorBalfe, Aine
dc.contributor.authorEarley, Helen
dc.contributor.authorDevane, Liam A
dc.contributor.authorLavelle, Aonghus
dc.contributor.authorWinter, Desmond C
dc.contributor.authorCoffey, J Calvin
dc.contributor.authorO'Connell, P Ronan
dc.date.accessioned2015-08-07T13:30:05Zen
dc.date.available2015-08-07T13:30:05Zen
dc.date.issued2014-04en
dc.identifier.citationInfluences of the colonic microbiome on the mucous gel layer in ulcerative colitis., 5 (3):277-85 Gut Microbesen
dc.identifier.issn1949-0984en
dc.identifier.pmid24714392en
dc.identifier.doi10.4161/gmic.28793en
dc.identifier.urihttp://hdl.handle.net/10147/565744en
dc.description.abstractThe colonic mucus gel layer (MGL) is a critical component of the innate immune system acting as a physical barrier to microbes, luminal insults, and toxins. Mucins are the major component of the MGL. Selected microbes have the potential to interact with, bind to, and metabolize mucins. The tolerance of the host to the presence of these microbes is critical to maintaining MGL homeostasis. In disease states such as ulcerative colitis (UC), both the mucosa associated microbes and the constituent MGL mucins have been shown to be altered. Evidence is accumulating that implicates the potential for mucin degrading bacteria to negatively impact the MGL and its stasis. These effects appear more pronounced in UC.   This review is focused on the host-microbiome interactions within the setting of the MGL. Special focus is given to the mucolytic potential of microbes and their interactions in the setting of the colitic colon.
dc.language.isoenen
dc.relation.urlhttp://www.tandfonline.com/doi/full/10.4161/gmic.28793en
dc.rightsArchived with thanks to Gut microbesen
dc.subject.meshBacteriaen
dc.subject.meshColitis, Ulcerativeen
dc.subject.meshColonen
dc.subject.meshHomeostasisen
dc.subject.meshHost-Pathogen Interactionsen
dc.subject.meshHumansen
dc.subject.meshMicrobiotaen
dc.subject.meshMucusen
dc.titleInfluences of the colonic microbiome on the mucous gel layer in ulcerative colitis.en
dc.typeArticleen
dc.identifier.journalGut microbesen
dc.description.fundingSFI Science Foundation Irelanden
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
refterms.dateFOA2018-08-27T03:14:36Z
html.description.abstractThe colonic mucus gel layer (MGL) is a critical component of the innate immune system acting as a physical barrier to microbes, luminal insults, and toxins. Mucins are the major component of the MGL. Selected microbes have the potential to interact with, bind to, and metabolize mucins. The tolerance of the host to the presence of these microbes is critical to maintaining MGL homeostasis. In disease states such as ulcerative colitis (UC), both the mucosa associated microbes and the constituent MGL mucins have been shown to be altered. Evidence is accumulating that implicates the potential for mucin degrading bacteria to negatively impact the MGL and its stasis. These effects appear more pronounced in UC.   This review is focused on the host-microbiome interactions within the setting of the MGL. Special focus is given to the mucolytic potential of microbes and their interactions in the setting of the colitic colon.


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