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    Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis.

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    ColonicMicrobiomeUlcerativeCol ...
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    Authors
    Lennon, Gráinne
    Balfe, Aine
    Earley, Helen
    Devane, Liam A
    Lavelle, Aonghus
    Winter, Desmond C
    Coffey, J Calvin
    O'Connell, P Ronan
    Issue Date
    2014-04
    MeSH
    Bacteria
    Colitis, Ulcerative
    Colon
    Homeostasis
    Host-Pathogen Interactions
    Humans
    Microbiota
    Mucus
    
    Metadata
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    Citation
    Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis., 5 (3):277-85 Gut Microbes
    Journal
    Gut microbes
    URI
    http://hdl.handle.net/10147/565744
    DOI
    10.4161/gmic.28793
    PubMed ID
    24714392
    Additional Links
    http://www.tandfonline.com/doi/full/10.4161/gmic.28793
    Abstract
    The colonic mucus gel layer (MGL) is a critical component of the innate immune system acting as a physical barrier to microbes, luminal insults, and toxins. Mucins are the major component of the MGL. Selected microbes have the potential to interact with, bind to, and metabolize mucins. The tolerance of the host to the presence of these microbes is critical to maintaining MGL homeostasis. In disease states such as ulcerative colitis (UC), both the mucosa associated microbes and the constituent MGL mucins have been shown to be altered. Evidence is accumulating that implicates the potential for mucin degrading bacteria to negatively impact the MGL and its stasis. These effects appear more pronounced in UC.   This review is focused on the host-microbiome interactions within the setting of the MGL. Special focus is given to the mucolytic potential of microbes and their interactions in the setting of the colitic colon.
    Item Type
    Article
    Language
    en
    ISSN
    1949-0984
    ae974a485f413a2113503eed53cd6c53
    10.4161/gmic.28793
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    St. Vincent's University Hospital

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