Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Issue Date
2014-12MeSH
AnimalsBiosensing Techniques
Brain
Contrast Media
Humans
Image Enhancement
Nanoparticles
Nanotechnology
Particle Size
Metadata
Show full item recordCitation
Nanotechnologies for the study of the central nervous system. 2014, 123:18-36 Prog. Neurobiol.Journal
Progress in neurobiologyDOI
10.1016/j.pneurobio.2014.09.004PubMed ID
25291406Additional Links
http://www.sciencedirect.com/science/article/pii/S030100821400104XAbstract
The impact of central nervous system (CNS) disorders on the human population is significant, contributing almost €800 billion in annual European healthcare costs. These disorders not only have a disabling social impact but also a crippling economic drain on resources. Developing novel therapeutic strategies for these disorders requires a better understanding of events that underlie mechanisms of neural circuit physiology. Studying the relationship between genetic expression, synapse development and circuit physiology in CNS function is a challenging task, involving simultaneous analysis of multiple parameters and the convergence of several disciplines and technological approaches. However, current gold-standard techniques used to study the CNS have limitations that pose unique challenges to furthering our understanding of functional CNS development. The recent advancement in nanotechnologies for biomedical applications has seen the emergence of nanoscience as a key enabling technology for delivering a translational bridge between basic and clinical research. In particular, the development of neuroimaging and electrophysiology tools to identify the aetiology and progression of CNS disorders have led to new insights in our understanding of CNS physiology and the development of novel diagnostic modalities for therapeutic intervention. This review focuses on the latest applications of these nanotechnologies for investigating CNS function and the improved diagnosis of CNS disorders.Item Type
ArticleLanguage
enISSN
1873-5118ae974a485f413a2113503eed53cd6c53
10.1016/j.pneurobio.2014.09.004
Scopus Count
Collections
Related articles
- Metal and metal oxide nanoparticles in chemiresistors: does the nanoscale matter?
- Authors: Franke ME, Koplin TJ, Simon U
- Issue date: 2006 Jan
- Liposome-nanoparticle hybrids for multimodal diagnostic and therapeutic applications.
- Authors: Al-Jamal WT, Kostarelos K
- Issue date: 2007 Feb
- Nanochannels preparation and application in biosensing.
- Authors: de la Escosura-Muñiz A, Merkoçi A
- Issue date: 2012 Sep 25
- Leveraging the interplay of nanotechnology and neuroscience: Designing new avenues for treating central nervous system disorders.
- Authors: Smith ES, Porterfield JE, Kannan RM
- Issue date: 2019 Aug
- Nanoparticles for photoacoustic imaging.
- Authors: Yang X, Stein EW, Ashkenazi S, Wang LV
- Issue date: 2009 Jul-Aug