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    The Impact of Immunosenescence on Pulmonary Disease.

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    Authors
    Murray, Michelle A
    Chotirmall, Sanjay H
    Affiliation
    1Department of Respiratory Medicine, Mater Misericordiae Hospital, Eccles Street, Dublin 7, Ireland. 2Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232.
    Issue Date
    2015-08
    Keywords
    POPLUATION HEALTH
    GLOBAL HEALTH
    
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    Citation
    The Impact of Immunosenescence on Pulmonary Disease. 2015, 2015:692546 Mediators Inflamm.
    Publisher
    Hindawi Publishing Corp.
    Journal
    Mediators of inflammation
    URI
    http://hdl.handle.net/10147/565675
    DOI
    10.1155/2015/692546
    PubMed ID
    26199462
    Abstract
    The global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred. Key facets of advancing age include genomic instability, telomere shortening, epigenetic changes, and declines in immune function termed immunosenescence. Immunosenescence and its associated chronic low grade systemic "inflamm-aging" contribute to the development and progression of pulmonary disease in older individuals. These physiological processes predispose to pulmonary infection and confer specific and unique clinical phenotypes observed in chronic respiratory disease including late-onset asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. Emerging concepts of the gut and airway microbiome further complicate the interrelationship between host and microorganism particularly from an immunological perspective and especially so in the setting of immunosenescence. This review focuses on our current understanding of the aging process, immunosenescence, and how it can potentially impact on various pulmonary diseases and the human microbiome.
    Item Type
    Article
    Language
    en
    ISSN
    1466-1861
    ae974a485f413a2113503eed53cd6c53
    10.1155/2015/692546
    Scopus Count
    Collections
    Mater Misericordiae Hospital

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