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dc.contributor.authorJohnson, Nichola
dc.contributor.authorDudbridge, Frank
dc.contributor.authorOrr, Nick
dc.contributor.authorGibson, Lorna
dc.contributor.authorJones, Michael E
dc.contributor.authorSchoemaker, Minouk J
dc.contributor.authorFolkerd, Elizabeth J
dc.contributor.authorHaynes, Ben P
dc.contributor.authorHopper, John L
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorDite, Gillian S
dc.contributor.authorApicella, Carmel
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorBroeks, Annegien
dc.contributor.authorVan’t Veer, Laura J
dc.contributor.authorAtsma, Femke
dc.contributor.authorMuir, Kenneth
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorFasching, Peter A
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authorEkici, Arif B
dc.contributor.authorRenner, Stefan P
dc.contributor.authorSawyer, Elinor
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael
dc.contributor.authorMiller, Nicola
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorMarme, Frederik
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorSohn, Christof
dc.contributor.authorGuénel, Pascal
dc.contributor.authorTruong, Therese
dc.contributor.authorCordina, Emilie
dc.contributor.authorMenegaux, Florence
dc.contributor.authorBojesen, Stig E
dc.contributor.authorNordestgaard, Børge G
dc.contributor.authorFlyger, Henrik
dc.contributor.authorMilne, Roger
dc.contributor.authorZamora, M P
dc.contributor.authorArias Perez, Jose I
dc.contributor.authorBenitez, Javier
dc.contributor.authorBernstein, Leslie
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorClarke Dur, Christina
dc.contributor.authorBrenner, Hermann
dc.contributor.authorMüller, Heiko
dc.contributor.authorArndt, Volker
dc.contributor.authorDieffenbach, Aida K
dc.contributor.authorMeindl, Alfons
dc.contributor.authorHeil, Joerg
dc.contributor.authorBartram, Claus R
dc.contributor.authorSchmutzler, Rita K
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorJustenhoven, Christina
dc.contributor.authorKo, Yon-Dschun
dc.contributor.authorThe GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorMuranen, Taru A
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorDörk, Thilo
dc.contributor.authorBogdanova, Natalia V
dc.contributor.authorAntonenkova, Natalia N
dc.contributor.authorLindblom, Annika
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKataja, Vesa
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana M
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorBeesley, Jonathan
dc.contributor.authorkConFab Investigators
dc.contributor.authorAustralian Ovarian Cancer Study Group
dc.contributor.authorWu, Anna H
dc.contributor.authorVan den Berg, David
dc.contributor.authorTseng, Chiu-Chen
dc.contributor.authorLambrechts, Diether
dc.contributor.authorSmeets, Dominiek
dc.contributor.authorNeven, Patrick
dc.contributor.authorWildiers, Hans
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorRudolph, Anja
dc.contributor.authorNickels, Stefan
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorRadice, Paolo
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorPensotti, Valeria
dc.contributor.authorCouch, Fergus J
dc.contributor.authorOlson, Janet E
dc.contributor.authorWang, Xianshu
dc.contributor.authorFredericksen, Zachary
dc.contributor.authorPankratz, Vernon S
dc.contributor.authorGiles, Graham G
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorBaglietto, Laura
dc.contributor.authorHaiman, Chris
dc.contributor.authorSimard, Jacques
dc.contributor.authorGoldberg, Mark S
dc.contributor.authorLabrèche, France
dc.contributor.authorDumont, Martine
dc.contributor.authorSoucy, Penny
dc.contributor.authorTeo, Soo
dc.contributor.authorYip, Cheng H
dc.contributor.authorPhuah, Sze Y
dc.contributor.authorCornes, Belinda K
dc.contributor.authorKristensen, Vessela N
dc.contributor.authorGrenaker Alnæs, Grethe
dc.contributor.authorBørresen-Dale, Anne-Lise
dc.contributor.authorZheng, Wei
dc.contributor.authorWinqvist, Robert
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorGrip, Mervi
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorKnight, Julia A
dc.contributor.authorGlendon, Gord
dc.contributor.authorMulligan, Anna M
dc.contributor.authorDevillee, Peter
dc.contributor.authorFigueroa, Jonine
dc.contributor.authorChanock, Stephen J
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorSherman, Mark E
dc.contributor.authorHall, Per
dc.contributor.authorSchoof, Nils
dc.contributor.authorHooning, Maartje
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorOldenburg, Rogier A
dc.contributor.authorTilanus-Linthorst, Madeleine
dc.contributor.authorLiu, Jianjun
dc.contributor.authorCox, Angie
dc.contributor.authorBrock, Ian W
dc.contributor.authorReed, Malcolm WR
dc.contributor.authorCross, Simon S
dc.contributor.authorBlot, William
dc.contributor.authorSignorello, Lisa B
dc.contributor.authorPharoah, Paul DP
dc.contributor.authorDunning, Alison M
dc.contributor.authorShah, Mitul
dc.contributor.authorKang, Daehee
dc.contributor.authorNoh, Dong-Young
dc.contributor.authorPark, Sue K
dc.contributor.authorChoi, Ji-Yeob
dc.contributor.authorHartman, Mikael
dc.contributor.authorMiao, Hui
dc.contributor.authorLim, Wei Y
dc.contributor.authorTang, Anthony
dc.contributor.authorHamann, Ute
dc.contributor.authorFörsti, Asta
dc.contributor.authorRüdiger, Thomas
dc.contributor.authorUlmer, Hans U
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubinski, Jan
dc.contributor.authorJaworska-Bieniek, Katarzyna
dc.contributor.authorDurda, Katarzyna
dc.contributor.authorSangrajrang, Suleeporn
dc.contributor.authorGaborieau, Valerie
dc.contributor.authorBrennan, Paul
dc.contributor.authorMcKay, James
dc.contributor.authorSlager, Susan
dc.contributor.authorToland, Amanda E
dc.contributor.authorVachon, Celine
dc.contributor.authorYannoukakos, Drakoulis
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorYu, Jyh-Cherng
dc.contributor.authorHuang, Chiun-Sheng
dc.contributor.authorHou, Ming-Feng
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorTessier, Daniel C
dc.contributor.authorVincent, Daniel
dc.contributor.authorBacot, Francois
dc.contributor.authorLuccarini, Craig
dc.contributor.authorDennis, Joe
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorWang, Jean
dc.contributor.authorEaston, Douglas F
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorDowsett, Mitch
dc.contributor.authorAshworth, Alan
dc.contributor.authorSwerdlow, Anthony J
dc.contributor.authorPeto, Julian
dc.contributor.authordos Santos Silva, Isabel
dc.contributor.authorFletcher, Olivia
dc.date.accessioned2015-07-14T14:35:58Zen
dc.date.available2015-07-14T14:35:58Zen
dc.date.issued2014-05-26en
dc.identifier.citationBreast Cancer Research. 2014 May 26;16(3):R51en
dc.identifier.urihttp://dx.doi.org/10.1186/bcr3662en
dc.identifier.urihttp://hdl.handle.net/10147/560427en
dc.description.abstractAbstract Introduction We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics. Results We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P trend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P trend = 0.005) but not cases (P trend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P het = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; P trend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; P trend = 0.29). Conclusions To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.
dc.language.isoenen
dc.subjectBREAST CANCERen
dc.subjectGENETICSen
dc.titleGenetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control studyen
dc.language.rfc3066enen
dc.rights.holderNichola Johnson et al.; licensee BioMed Central Ltd.en
dc.description.statusPeer Revieweden
dc.date.updated2015-02-04T16:03:58Zen
refterms.dateFOA2018-08-08T14:19:05Z
html.description.abstractAbstract Introduction We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics. Results We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P trend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P trend = 0.005) but not cases (P trend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P het = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; P trend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; P trend = 0.29). Conclusions To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.


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