PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.
Authors
Bowes, JohnLoehr, Sabine
Budu-Aggrey, Ashley
Uebe, Steffen
Bruce, Ian N
Feletar, Marie
Marzo-Ortega, Helena
Helliwell, Philip
Ryan, Anthony W
Kane, David
Korendowych, Eleanor
Alenius, Gerd-Marie
Giardina, Emiliano
Packham, Jonathan
McManus, Ross
FitzGerald, Oliver
Brown, Matthew A
Behrens, Frank
Burkhardt, Harald
McHugh, Neil
Huffmeier, Ulrike
Ho, Pauline
Reis, Andre
Barton, Anne
Affiliation
1Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. 2Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany. 3Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. 4Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK. 5Monash University, Melbourne, Victoria, Australia. 6NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK. 7Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland. 8Adelaide and Meath Hospital and Trinity College Dublin, Dublin, Ireland. 9Royal National Hospital for Rheumatic Diseases and Department Pharmacy and Pharmacology, University of Bath, Bath, UK. 10Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, Umeå, Sweden. 11Department of Biopathology, Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, University of Rome 'Tor Vergata' and Fondazione PTV 'Policlinico Tor Vergata', Rome, Italy. 12Rheumatology Department, Haywood Hospital, Health Services Research Unit, Institute of Science and Technology in Medicine, Keele University. 13Department of Rheumatology, St. Vincent's University Hospital, UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. 14The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, Queensland, Australia. 15Division of Rheumatology and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany. 16Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.Issue Date
2015-04-28Keywords
GENETICSARTHRITIS
Metadata
Show full item recordCitation
PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus. 2015: Ann. Rheum. Dis.Publisher
BMJJournal
Annals of the rheumatic diseasesDOI
10.1136/annrheumdis-2014-207187PubMed ID
25923216Abstract
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA.Item Type
ReportLanguage
enISSN
1468-2060ae974a485f413a2113503eed53cd6c53
10.1136/annrheumdis-2014-207187