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    Fasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The Diabetes Mellitus and Vascular health initiative (DMVhi).

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    Authors
    Sinnott, M
    Kinsley, BT
    Jackson, AD
    Walsh, C
    O'Grady, T
    Nolan, JJ
    Gaffney, P
    Boran, G
    Kelleher, C
    Carr, B
    Affiliation
    1Vhi Healthcare Ltd, Dublin, Republic of Ireland. 2Mater Misericordiae University Hospital, Dublin, Republic of Ireland. 3Department of Statistics, Trinity College Dublin, Dublin, Republic of Ireland. 4Steno Diabetes Center, DK-2820 Gentofte, Denmark. 5The Adelaide and Meath Hospital incorporating the National Children's Hospital, Dublin, Republic of Ireland. 6University College Dublin School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Republic of Ireland. 7Vhi Healthcare Ltd, Dublin, Republic of Ireland; University College Dublin School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Republic of Ireland.
    Issue Date
    2015-04-15
    Keywords
    DIABETES
    SCREENING
    
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    Citation
    Sinnott M, Kinsley BT, Jackson AD, Walsh C, O’Grady T, Nolan JJ, et al. (2015) Fasting Plasma Glucose as Initial Screening for Diabetes and Prediabetes in Irish Adults: The Diabetes Mellitus and Vascular Health Initiative (DMVhi). PLoS ONE 10(4): e0122704. doi:10.1371/journal.pone.0122704
    Publisher
    Public Library of Science (PLoS One)
    Journal
    PLOS ONE
    URI
    http://hdl.handle.net/10147/559045
    Additional Links
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122704
    Abstract
    Objective Type 2 diabetes has a long pre clinical asymptomatic phase. Early detection may delay or arrest disease progression. The Diabetes Mellitus and Vascular health initiative (DMVhi) was initiated as a prospective longitudinal cohort study on the prevalence of undiagnosed Type 2 diabetes and prediabetes, diabetes risk and cardiovascular risk in a cohort of Irish adults aged 45-75 years. Research Design and Methods Members of the largest Irish private health insurance provider aged 45 to 75 years were invited to participate in the study. Exclusion criteria: already diagnosed with diabetes or taking oral hypoglycaemic agents. Participants completed a detailed medical questionnaire, had weight, height, waist and hip circumference and blood pressure measured. Fasting blood samples were taken for fasting plasma glucose (FPG). Those with FPG in the impaired fasting glucose (IFG) range had a 75gm oral glucose tolerance test performed. Results 122,531 subjects were invited to participate. 29,144 (24%) completed the study. The prevalence of undiagnosed diabetes was 1.8%, of impaired fasting glucose (IFG) was 7.1% and of impaired glucose tolerance (IGT) was 2.9%. Dysglycaemia increased among those aged 45-54, 55-64 and 65-75 years in both males (10.6%, 18.5%, 21.7% respectively) and females (4.3%, 8.6%, 10.9% respectively). Undiagnosed T2D, IFG and IGT were all associated with gender, age, blood pressure, BMI, abdominal obesity, family history of diabetes and triglyceride levels. Using FPG as initial screening may underestimate the prevalence of T2D in the study population. Conclusions This study is the largest screening study for diabetes and prediabetes in the Irish population. Follow up of this cohort will provide data on progression to diabetes and on cardiovascular outcomes.
    Item Type
    Article
    Language
    en
    Sponsors
    Funder:DMVhi research project was funded by Vhi Healthcare. Part funding was received for the project through the EU-funded DEXLIFE ressearch program. Vhi Healthcare Ltd., provided support in the form of salaries for authors MS, ADJ, TOG & BC, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.
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