• The impact of meningococcal polymerase chain reaction testing on laboratory confirmation of invasive meningococcal disease.

      Drew, Richard J; Ó Maoldomhnaigh, Cilian; Gavin, Patrick J; O' Sullivan, Nicola; Butler, Karina M; Cafferkey, Mary; Irish Meningococcal and Meningitis Reference Laboratory (IMMRL), The Children's University Hospital, Dublin, Ireland. richard.drew@alderhey.nhs.uk (2012-03)
      Laboratory methods of diagnosis were examined for 266 children with invasive meningococcal disease. Seventy-five (36%) of 207 cases with bloodstream infection had both positive blood culture and blood meningococcal polymerase chain reaction (PCR), 130 (63%) negative blood culture and positive blood PCR, and 2 (1%) had positive blood culture and negative blood PCR. Sixty-three percent of cases were diagnosed by PCR alone.