Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia.
Carvalho, Jose C A
AffiliationDepartment of Anesthesia, Mount Sinai Hospital, University of Toronto, Toronto ON.
Local subject classificationPRE-ECLAMPSIA
Vascular Endothelial Growth Factor Receptor-1
MetadataShow full item record
CitationDoherty, A. et al., 2014. Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia. Journal of Obstetrics and Gynaecology Canada, 36 (8):692-700
JournalJournal of Obstetrics and Gynaecology Canada : JOGC - Journal d'obstétrique et gynécologie du Canada : JOGC
AbstractEarly identification of women at risk of developing early-onset severe preeclampsia (sPE) is a key objective in obstetrics. An elevated ratio of serum soluble fms-like tyrosine kinase (sFlt-1) to placenta-like growth factor (PlGF) (sFlt-1/PlGF ratio) precedes overt hypertension. The longitudinal relationship between this biomarker, maternal hemodynamics, and maternal serum uric acid during the pre-clinical phase is unknown.
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