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    The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide

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    Authors
    Cooke, Jonathan
    Dryden, Matthew
    Patton, Thomas
    Brennan, James
    Barrett, John
    Issue Date
    2015-01-28
    Keywords
    FOOD
    NUTRITION
    Local subject classification
    MICROBIOLOGY
    
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    Citation
    Cooke, J. et al., 2015. The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide. BMC Research Notes. 2015 Jan 28;8(1):20
    URI
    http://dx.doi.org/10.1186/s13104-014-0960-4
    http://hdl.handle.net/10147/346202
    Abstract
    Abstract Background Antimicrobial resistance continues to be a global issue in healthcare organisations. Honey has long been shown to possess wound healing and antimicrobial properties that are dependent on a number of physical and chemical properties of the honey. We tested the antimicrobial activity of a medicinal honey, Surgihoney® (SH) and two prototype modified honeys made by Apis mellifera (honeybee) against Staphylococcus aureus (NCIMB 9518). We also examined the modified honey prototypes for the ability to generate reactive oxygen species (ROS) by changing the level of production of hydrogen peroxide from the samples. Methods Surgihoney® (SH) was compared with two modified honeys, Prototype 1 (PT1) and Prototype 2 (PT2) using a bioassay method against a standard strain of Staphylococcus aureus. Further work studied the rate of generation of ROS hydrogen peroxide from these preparations. Results Surgihoney® antimicrobial activity was shown to be largely due to ROS hydrogen peroxide production. By modification of Surgihoney®, two more potent honey prototypes were shown to generate between a two- and three-fold greater antibacterial activity and up to ten times greater ROS peroxide activity. Conclusions Surgihoney® is a clinically available wound antiseptic dressing that shows good antimicrobial activity. Two further honey prototypes have been shown to have antimicrobial activity that is possible to be enhanced due to demonstrated increases in ROS peroxide activity.
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