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dc.contributor.authorAbbah, Sunny A
dc.contributor.authorSpanoudes, Kyriakos
dc.contributor.authorO’Brien, Timothy
dc.contributor.authorPandit, Abhay
dc.contributor.authorZeugolis, Dimitrios I
dc.date.accessioned2015-02-17T12:16:59Zen
dc.date.available2015-02-17T12:16:59Zen
dc.date.issued2014-03-18en
dc.identifier.citationStem Cell Research & Therapy. 2014 Mar 18;5(2):38en
dc.identifier.urihttp://dx.doi.org/10.1186/scrt426en
dc.identifier.urihttp://hdl.handle.net/10147/344531en
dc.description.abstractAbstract Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional recovery, imposing the need for the development of therapeutic strategies. The limited number of low activity/reparative capacity tendon-resident cells has directed substantial research efforts towards the exploration of the therapeutic potential of various stem cells in tendon injuries and pathophysiologies. Severe injuries require the use of a stem cell carrier to enable cell localisation at the defect site. The present study describes advancements that injectable carriers, tissue grafts, anisotropically orientated biomaterials, and cell-sheets have achieved in preclinical models as stem cell carriers for tendon repair.
dc.language.isoenen
dc.subject.otherPRE CLINICAL MODELSen
dc.subject.otherSTEM CELL RESEARCHen
dc.titleAssessment of stem cell carriers for tendon tissue engineering in pre-clinical modelsen
dc.language.rfc3066en
dc.rights.holderSunny Akogwu Abbah et al.; licensee BioMed Central Ltd.
dc.description.statusPeer Reviewed
dc.date.updated2015-02-03T08:04:09Z
refterms.dateFOA2018-08-25T00:50:14Z
html.description.abstractAbstract Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional recovery, imposing the need for the development of therapeutic strategies. The limited number of low activity/reparative capacity tendon-resident cells has directed substantial research efforts towards the exploration of the therapeutic potential of various stem cells in tendon injuries and pathophysiologies. Severe injuries require the use of a stem cell carrier to enable cell localisation at the defect site. The present study describes advancements that injectable carriers, tissue grafts, anisotropically orientated biomaterials, and cell-sheets have achieved in preclinical models as stem cell carriers for tendon repair.


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