Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models

Abbah, Sunny A; Spanoudes, Kyriakos; O’Brien, Timothy; Pandit, Abhay; Zeugolis, Dimitrios I

dc.contributor.author	Abbah, Sunny A
dc.contributor.author	Spanoudes, Kyriakos
dc.contributor.author	O’Brien, Timothy
dc.contributor.author	Pandit, Abhay
dc.contributor.author	Zeugolis, Dimitrios I
dc.date.accessioned	2015-02-17T12:16:59Z	en
dc.date.available	2015-02-17T12:16:59Z	en
dc.date.issued	2014-03-18	en
dc.identifier.citation	Stem Cell Research & Therapy. 2014 Mar 18;5(2):38	en
dc.identifier.uri	http://dx.doi.org/10.1186/scrt426	en
dc.identifier.uri	http://hdl.handle.net/10147/344531	en
dc.description.abstract	Abstract Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional recovery, imposing the need for the development of therapeutic strategies. The limited number of low activity/reparative capacity tendon-resident cells has directed substantial research efforts towards the exploration of the therapeutic potential of various stem cells in tendon injuries and pathophysiologies. Severe injuries require the use of a stem cell carrier to enable cell localisation at the defect site. The present study describes advancements that injectable carriers, tissue grafts, anisotropically orientated biomaterials, and cell-sheets have achieved in preclinical models as stem cell carriers for tendon repair.
dc.language.iso	en	en
dc.subject.other	PRE CLINICAL MODELS	en
dc.subject.other	STEM CELL RESEARCH	en
dc.title	Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models	en
dc.language.rfc3066	en
dc.rights.holder	Sunny Akogwu Abbah et al.; licensee BioMed Central Ltd.
dc.description.status	Peer Reviewed
dc.date.updated	2015-02-03T08:04:09Z
refterms.dateFOA	2018-08-25T00:50:14Z
html.description.abstract	Abstract Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional recovery, imposing the need for the development of therapeutic strategies. The limited number of low activity/reparative capacity tendon-resident cells has directed substantial research efforts towards the exploration of the therapeutic potential of various stem cells in tendon injuries and pathophysiologies. Severe injuries require the use of a stem cell carrier to enable cell localisation at the defect site. The present study describes advancements that injectable carriers, tissue grafts, anisotropically orientated biomaterials, and cell-sheets have achieved in preclinical models as stem cell carriers for tendon repair.