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    Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme.

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    Authors
    Stack, Austin G
    Casserly, Liam F
    Cronin, Cornelius J
    Chernenko, Tetyana
    Cullen, Walter
    Hannigan, Ailish
    Saran, Rajiv
    Johnson, Howard
    Browne, Gemma
    Ferguson, John P
    Affiliation
    Departments of Nephrology and Internal Medicine, University Hospital Limerick, Limerick, Ireland. austin.stack@ul.ie.
    Issue Date
    2014
    Keywords
    KIDNEY DISEASE
    HEALTH SERVICES
    
    Metadata
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    Citation
    Stack, A.G. et al., 2014. Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme. BMC Nephrology. 15:185
    Journal
    BMC nephrology
    URI
    http://hdl.handle.net/10147/337125
    DOI
    10.1186/1471-2369-15-185
    PubMed ID
    25425510
    Abstract
    Chronic Kidney Disease (CKD) is a major non-communicable chronic disease that is associated with adverse clinical and economic outcomes. Passive surveillance systems are likely to improve efforts for prevention of chronic kidney disease (CKD) and inform national service planning. This study was conducted to determine the overall prevalence of CKD in the Irish health system, assess period trends and explore patterns of variation as part of a novel surveillance initiative.
    We identified 207, 336 adult patients, age 18 and over, with serum creatinine measurements recorded from a provincial database between 2005-2011 in the Northwest of Ireland. Estimated glomerular filtration rates (eGFR) were determined using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation from standardized creatinine measurements and the presence of CKD was defined as eGFR <60 ml/min per 1.73 m2. Age and sex-specific prevalence estimates were determined for each group while generalized estimating equations (GEE) and multivariable logistic regression were used to explore associations using adjusted odds ratios (AOR) and 95% confidence intervals (95% CI).
    The prevalence of CKD in the health system was 11.8% (95% CI 11.8-12.1); 10.9% in men (10.7-11.1) and 12.6% in women (12.4-12.8). This corresponded to a detection rate of 4.5% (5.1% in women and 3.9% in men). The prevalence of CKD was significantly higher in women than in men (12.6% versus 10.9%, P < 0.001), older age groups, and among patients with a history of Acute Kidney Injury (AKI) than without (45.2% versus 10.7%, P < 0.0001). Multivariable analysis identified advancing age, female gender, location of medical supervision, county of residence, and AKI as significant determinants of prevalence.
    The prevalence of CKD in the Irish health system is 11.8% corresponding to a detection rate of 4.5% in the general population. Demographic, geographic factors and acute kidney injury episodes are important determinants of disease burden. Passive surveillance of CKD is both feasible and desirable within the Irish health system, and offers huge opportunities for targeted prevention programmes and improved clinical outcomes.
    Item Type
    Article
    Language
    en
    ISSN
    1471-2369
    ae974a485f413a2113503eed53cd6c53
    10.1186/1471-2369-15-185
    Scopus Count
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