Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine.
Affiliation1 Irish National Lung and Heart Transplant Program, Mater Misericordiae University Hospital, Dublin, Ireland.
Local subject classificationLUNG CONDITIONS
Disease Models, Animal
Translational Medical Research
MetadataShow full item record
CitationAnatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine. 2014, 51 (3):334-43 Am. J. Respir. Cell Mol. Biol.
JournalAmerican journal of respiratory cell and molecular biology
AbstractThe porcine model has contributed significantly to biomedical research over many decades. The similar size and anatomy of pig and human organs make this model particularly beneficial for translational research in areas such as medical device development, therapeutics and xenotransplantation. In recent years, a major limitation with the porcine model was overcome with the successful generation of gene-targeted pigs and the publication of the pig genome. As a result, the role of this model is likely to become even more important. For the respiratory medicine field, the similarities between pig and human lungs give the porcine model particular potential for advancing translational medicine. An increasing number of lung conditions are being studied and modeled in the pig. Genetically modified porcine models of cystic fibrosis have been generated that, unlike mouse models, develop lung disease similar to human cystic fibrosis. However, the scientific literature relating specifically to porcine lung anatomy and airway histology is limited and is largely restricted to veterinary literature and textbooks. Furthermore, methods for in vivo lung procedures in the pig are rarely described. The aims of this review are to collate the disparate literature on porcine lung anatomy, histology, and microbiology; to provide a comparison with the human lung; and to describe appropriate bronchoscopy procedures for the pig lungs to aid clinical researchers working in the area of translational respiratory medicine using the porcine model.
- Xenotransplantation of solid organs in the pig-to-primate model.
- Authors: Ekser B, Rigotti P, Gridelli B, Cooper DK
- Issue date: 2009 Jun
- Unraveling the swine genome: implications for human health.
- Authors: Schook LB, Collares TV, Darfour-Oduro KA, De AK, Rund LA, Schachtschneider KM, Seixas FK
- Issue date: 2015
- The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 5: Strategies to prevent transmission of porcine endogenous retroviruses.
- Authors: Denner J, Schuurman HJ, Patience C
- Issue date: 2009 Jul-Aug
- Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases.
- Authors: Cooper DK, Keogh AM, Brink J, Corris PA, Klepetko W, Pierson RN, Schmoeckel M, Shirakura R, Warner Stevenson L, Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation.
- Issue date: 2000 Dec
- Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies.
- Authors: Klymiuk N, Seeliger F, Bohlooly-Y M, Blutke A, Rudmann DG, Wolf E
- Issue date: 2016 Apr