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    Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease

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    Authors
    Dowling, Paul
    Hayes, Catriona
    Ting, Kay R
    Hameed, Abdul
    Meiller, Justine
    Mitsiades, Constantine
    Anderson, Kenneth C
    Clynes, Martin
    Clarke, Colin
    Richardson, Paul
    O’Gorman, Peter
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    Issue Date
    2014-10-17
    Keywords
    BONE DENSITY
    Local subject classification
    BONE DISEASE
    GENOMICS
    
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    Citation
    BMC Genomics. 2014 Oct 17;15(1):904
    URI
    http://dx.doi.org/10.1186/1471-2164-15-904
    http://hdl.handle.net/10147/333615
    Abstract
    Abstract Background Bone destruction is a feature of multiple myeloma, characterised by osteolytic bone destruction due to increased osteoclast activity and suppressed or absent osteoblast activity. Almost all multiple myeloma patients develop osteolytic bone lesions associated with severe and debilitating bone pain, pathologic fractures, hypercalcemia, and spinal cord compression, as well as increased mortality. Biomarkers of bone remodelling are used to identify disease characteristics that can help select the optimal management of patients. However, more accurate biomarkers are needed to effectively mirror the dynamics of bone disease activity. Results A label-free mass spectrometry-based strategy was employed for discovery phase analysis of fractionated patient serum samples associated with no or high bone disease. A number of proteins were identified which were statistically significantly correlated with bone disease, including enzymes, extracellular matrix glycoproteins, and components of the complement system. Conclusions Enzyme-linked immunosorbent assay of complement C4 and serum paraoxonase/arylesterase 1 indicated that these proteins were associated with high bone disease in a larger independent cohort of patient samples. These biomolecules may therefore be clinically useful in assessing the extent of bone disease.
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    en
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