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    Proteomics in uveal melanoma.

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    Authors
    Ramasamy, Pathma
    Murphy, Conor C
    Clynes, Martin
    Horgan, Noel
    Moriarty, Paul
    Tiernan, Damien
    Beatty, Stephen
    Kennedy, Susan
    Meleady, Paula
    Affiliation
    Royal College of Surgeons Ireland, Stephen's Green, Dublin 2, Ireland; National Institute for Cellular Biotechnology, Dublin City University, Collins Avenue, Glasnevin, Dublin 9, Ireland. Electronic address: Pathma.Ramasamy@dcu.ie.
    Issue Date
    2014-01
    Keywords
    CANCER
    EYE DISORDER
    MeSH
    Humans
    Melanoma
    Proteomics
    Tumor Markers, Biological
    Uveal Neoplasms
    
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    Citation
    Ramasamy, P. et al., 2014. Proteomics in uveal melanoma. Experimental Eye Research, 118 (1), pp 1-12
    Journal
    Experimental eye research
    URI
    http://hdl.handle.net/10147/333014
    DOI
    10.1016/j.exer.2013.09.005
    PubMed ID
    24056206
    Abstract
    Uveal melanoma is the most common primary intraocular malignancy in adults, with an incidence of 5-7 per million per year. It is associated with the development of metastasis in about 50% of cases, and 40% of patients with uveal melanoma die of metastatic disease despite successful treatment of the primary tumour. The survival rates at 5, 10 and 15 years are 65%, 50% and 45% respectively. Unlike progress made in many other areas of cancer, uveal melanoma is still poorly understood and survival rates have remained similar over the past 25 years. Recently, advances made in molecular genetics have improved our understanding of this disease and stratification of patients into low risk and high risk for developing metastasis. However, only a limited number of studies have been performed using proteomic methods. This review will give an overview of various proteomic technologies currently employed in life sciences research, and discuss proteomic studies of uveal melanoma.
    Item Type
    Article
    Language
    en
    ISSN
    1096-0007
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.exer.2013.09.005
    Scopus Count
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    Royal Victoria Eye and Ear Hospital

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