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dc.contributor.authorO'Dwyer, David N
dc.contributor.authorArmstrong, Michelle E
dc.contributor.authorCooke, Gordon
dc.contributor.authorDodd, Jonathan D
dc.contributor.authorVeale, Douglas J
dc.contributor.authorDonnelly, Seamas C
dc.date.accessioned2014-10-16T11:40:21Z
dc.date.available2014-10-16T11:40:21Z
dc.date.issued2013-10
dc.identifier.citationO'Dwyer, DN et al. Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD). Eur. J. Intern. Med. 2013, 24 (7):597-603en_GB
dc.identifier.issn1879-0828
dc.identifier.pmid23916467
dc.identifier.doi10.1016/j.ejim.2013.07.004
dc.identifier.urihttp://hdl.handle.net/10147/332799
dc.description.abstractRheumatoid Arthritis (RA) is the most common Connective Tissue Disease (CTD) and represents an increasing burden on global health resources. Interstitial lung disease (ILD) has been recognised as a complication of RA but its potential for mortality and morbidity has arguably been under appreciated for decades. New studies have underscored a significant lifetime risk of ILD development in RA. Contemporary work has identified an increased risk of mortality associated with the Usual Interstitial Pneumonia (UIP) pattern which shares similarity with the most devastating of the interstitial pulmonary diseases, namely Idiopathic Pulmonary Fibrosis (IPF). In this paper, we discuss recent studies highlighting the associated increase in mortality in RA-UIP. We explore associations between radiological and histopathological features of RA-ILD and the prognostic implications of same. We emphasise the need for translational research in this area given the growing burden of RA-ILD. We highlight the importance of the respiratory physician as a key stakeholder in the multidisciplinary management of this disorder. RA-ILD focused research offers the opportunity to identify early asymptomatic disease and define the natural history of this extra articular manifestation. This may provide a unique opportunity to define key regulatory fibrotic events driving progressive disease. We also discuss some of the more challenging and novel aspects of therapy for RA-ILD.
dc.language.isoenen
dc.rightsArchived with thanks to European journal of internal medicineen_GB
dc.subjectRESPIRATORY DISORDERen_GB
dc.subject.meshArthritis, Rheumatoid
dc.subject.meshHumans
dc.subject.meshLung Diseases, Interstitial
dc.subject.meshPulmonary Fibrosis
dc.subject.meshRisk Factors
dc.subject.otherRHEUMATOID ARTHRITISen_GB
dc.subject.otherINTERSTITIAL LUNG DISEASEen_GB
dc.titleRheumatoid Arthritis (RA) associated interstitial lung disease (ILD).en_GB
dc.typeArticleen
dc.contributor.departmentSchool of Medicine and Medical Science, College of Life Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland; National Pulmonary Fibrosis Referral Centre at St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.en_GB
dc.identifier.journalEuropean journal of internal medicineen_GB
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
html.description.abstractRheumatoid Arthritis (RA) is the most common Connective Tissue Disease (CTD) and represents an increasing burden on global health resources. Interstitial lung disease (ILD) has been recognised as a complication of RA but its potential for mortality and morbidity has arguably been under appreciated for decades. New studies have underscored a significant lifetime risk of ILD development in RA. Contemporary work has identified an increased risk of mortality associated with the Usual Interstitial Pneumonia (UIP) pattern which shares similarity with the most devastating of the interstitial pulmonary diseases, namely Idiopathic Pulmonary Fibrosis (IPF). In this paper, we discuss recent studies highlighting the associated increase in mortality in RA-UIP. We explore associations between radiological and histopathological features of RA-ILD and the prognostic implications of same. We emphasise the need for translational research in this area given the growing burden of RA-ILD. We highlight the importance of the respiratory physician as a key stakeholder in the multidisciplinary management of this disorder. RA-ILD focused research offers the opportunity to identify early asymptomatic disease and define the natural history of this extra articular manifestation. This may provide a unique opportunity to define key regulatory fibrotic events driving progressive disease. We also discuss some of the more challenging and novel aspects of therapy for RA-ILD.


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