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    Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD).

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    Authors
    O'Dwyer, David N
    Armstrong, Michelle E
    Cooke, Gordon
    Dodd, Jonathan D
    Veale, Douglas J
    Donnelly, Seamas C
    Affiliation
    School of Medicine and Medical Science, College of Life Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland; National Pulmonary Fibrosis Referral Centre at St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
    Issue Date
    2013-10
    Keywords
    RESPIRATORY DISORDER
    Local subject classification
    RHEUMATOID ARTHRITIS
    INTERSTITIAL LUNG DISEASE
    MeSH
    Arthritis, Rheumatoid
    Humans
    Lung Diseases, Interstitial
    Pulmonary Fibrosis
    Risk Factors
    
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    Citation
    O'Dwyer, DN et al. Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD). Eur. J. Intern. Med. 2013, 24 (7):597-603
    Journal
    European journal of internal medicine
    URI
    http://hdl.handle.net/10147/332799
    DOI
    10.1016/j.ejim.2013.07.004
    PubMed ID
    23916467
    Abstract
    Rheumatoid Arthritis (RA) is the most common Connective Tissue Disease (CTD) and represents an increasing burden on global health resources. Interstitial lung disease (ILD) has been recognised as a complication of RA but its potential for mortality and morbidity has arguably been under appreciated for decades. New studies have underscored a significant lifetime risk of ILD development in RA. Contemporary work has identified an increased risk of mortality associated with the Usual Interstitial Pneumonia (UIP) pattern which shares similarity with the most devastating of the interstitial pulmonary diseases, namely Idiopathic Pulmonary Fibrosis (IPF). In this paper, we discuss recent studies highlighting the associated increase in mortality in RA-UIP. We explore associations between radiological and histopathological features of RA-ILD and the prognostic implications of same. We emphasise the need for translational research in this area given the growing burden of RA-ILD. We highlight the importance of the respiratory physician as a key stakeholder in the multidisciplinary management of this disorder. RA-ILD focused research offers the opportunity to identify early asymptomatic disease and define the natural history of this extra articular manifestation. This may provide a unique opportunity to define key regulatory fibrotic events driving progressive disease. We also discuss some of the more challenging and novel aspects of therapy for RA-ILD.
    Item Type
    Article
    Language
    en
    ISSN
    1879-0828
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejim.2013.07.004
    Scopus Count
    Collections
    St. Vincent's University Hospital

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