The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence.
Affiliation
Department of Laboratory Medicine, Rotunda Hospital, Dublin, Ireland.Issue Date
2014-06-12Keywords
PREGNANCYLocal subject classification
FOETO-MATERNAL HAEMORRHAGE
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Corcoran D et al. The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence. Blood Transfus. 2014:1-5Journal
Blood Transfusion = Trasfusione del sangueDOI
10.2450/2014.0297-13PubMed ID
24960639Abstract
Acid elution (AE) is used to estimate foeto-maternal haemorrhage (FMH). However AE cannot differentiate between cells containing foetal or adult haemoglobin F (F cells), potentially leading to false positive results or an overestimate of the amount of FMH. The prevalence of F cells in pregnant populations remains poorly characterised. The purpose of this study was to ascertain the incidence of HbF-containing red cells in our pregnant population using anti-HbF-fluorescein isothiocyanate flow cytometry (anti-HbF FC) and to assess whether its presence leads to a significant overestimate of FMH.Item Type
ArticleLanguage
enISSN
1723-2007ae974a485f413a2113503eed53cd6c53
10.2450/2014.0297-13
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