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    The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence.

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    Authors
    Corcoran, Deirdre
    Murphy, Deirdre
    Donnelly, Jennifer C
    Ainle, Fionnuala Ni
    Affiliation
    Department of Laboratory Medicine, Rotunda Hospital, Dublin, Ireland.
    Issue Date
    2014-06-12
    Keywords
    PREGNANCY
    Local subject classification
    FOETO-MATERNAL HAEMORRHAGE
    
    Metadata
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    Citation
    Corcoran D et al. The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence. Blood Transfus. 2014:1-5
    Journal
    Blood Transfusion = Trasfusione del sangue
    URI
    http://hdl.handle.net/10147/326349
    DOI
    10.2450/2014.0297-13
    PubMed ID
    24960639
    Abstract
    Acid elution (AE) is used to estimate foeto-maternal haemorrhage (FMH). However AE cannot differentiate between cells containing foetal or adult haemoglobin F (F cells), potentially leading to false positive results or an overestimate of the amount of FMH. The prevalence of F cells in pregnant populations remains poorly characterised. The purpose of this study was to ascertain the incidence of HbF-containing red cells in our pregnant population using anti-HbF-fluorescein isothiocyanate flow cytometry (anti-HbF FC) and to assess whether its presence leads to a significant overestimate of FMH.
    Item Type
    Article
    Language
    en
    ISSN
    1723-2007
    ae974a485f413a2113503eed53cd6c53
    10.2450/2014.0297-13
    Scopus Count
    Collections
    Rotunda Hospital

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