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    Global DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - A pilot study.

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    Authors
    Tsang, J S
    Vencken, S
    Sharaf, O
    Leen, E
    Kay, E W
    McNamara, D A
    Deasy, J
    Mulligan, E D
    Affiliation
    Department of Surgical Research, Connolly Hospital & RCSI, Blanchardstown, Dublin, Ireland. Electronic address: julianst@yahoo.com.
    Issue Date
    2014-07-28
    Keywords
    CANCER
    MEDICAL TREATMENT
    Local subject classification
    CANCER, RECTAL
    CHEMOTHERAPY
    RADIOTHERAPY
    
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    Citation
    Tsang JS et al. Global DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - a pilot study. Eur J Surg Oncol 2014
    Journal
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
    URI
    http://hdl.handle.net/10147/325912
    DOI
    10.1016/j.ejso.2014.06.008
    PubMed ID
    25108814
    Abstract
    In rectal cancer, not all tumours display a response to neoadjuvant treatment. An accurate predictor of response does not exist to guide patient-specific treatment. DNA methylation is a distinctive molecular pathway in colorectal carcinogenesis. Whether DNA methylation is altered by neoadjuvant treatment and a potential response predictor is unknown. We aimed to determine whether DNA methylation is altered by neoadjuvant chemoradiotherapy (CRT) and to determine its role in predicting response to treatment.
    Item Type
    Article
    Language
    en
    ISSN
    1532-2157
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejso.2014.06.008
    Scopus Count
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    Connolly Hospital

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