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dc.contributor.authorBest, Kate E
dc.contributor.authorTennant, Peter W G
dc.contributor.authorAddor, Marie-Claude
dc.contributor.authorBianchi, Fabrizio
dc.contributor.authorBoyd, Patricia
dc.contributor.authorCalzolari, Elisa
dc.contributor.authorDias, Carlos Matias
dc.contributor.authorDoray, Berenice
dc.contributor.authorDraper, Elizabeth
dc.contributor.authorGarne, Ester
dc.contributor.authorGatt, Miriam
dc.contributor.authorGreenlees, Ruth
dc.contributor.authorHaeusler, Martin
dc.contributor.authorKhoshnood, Babak
dc.contributor.authorMcDonnell, Bob
dc.contributor.authorMullaney, Carmel
dc.contributor.authorNelen, Vera
dc.contributor.authorRandrianaivo, Hanitra
dc.contributor.authorRissmann, Anke
dc.contributor.authorSalvador, Joaquin
dc.contributor.authorTucker, David
dc.contributor.authorWellesly, Diana
dc.contributor.authorRankin, Judith
dc.date.accessioned2014-08-05T08:57:11Z
dc.date.available2014-08-05T08:57:11Z
dc.date.issued2012-09
dc.identifier.citationBest KE et al. Epidemiology of small intestinal atresia in Europe: a register-based study. 2012, 97 (5):F353-8 Arch. Dis. Child. Fetal Neonatal Ed.en_GB
dc.identifier.issn1468-2052
dc.identifier.pmid22933095
dc.identifier.doi10.1136/fetalneonatal-2011-300631
dc.identifier.urihttp://hdl.handle.net/10147/324196
dc.descriptionBACKGROUND: The epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe. METHODS: Cases of SIA delivered during January 1990 to December 2006 notified to 20 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept. RESULTS: In total 1133 SIA cases were reported among 5126, 164 registered births. Of 1044 singleton cases, 215 (20.6%) cases were associated with a chromosomal anomaly. Of 829 singleton SIA cases with normal karyotype, 221 (26.7%) were associated with other structural anomalies. Considering cases with normal karyotype, the total prevalence per 10 000 births was 1.6 (95% CI 1.5 to 1.7) for SIA, 0.9 (95% CI 0.8 to 1.0) for duodenal atresia and 0.7 (95% CI 0.7 to 0.8) for jejunoileal atresia (JIA). There was no significant trend in SIA, duodenal atresia or JIA prevalence over time (RR=1.0, 95% credible interval (CrI): 1.0 to 1.0 for each), but SIA and duodenal atresia prevalence varied by geographical location (p=0.03 and p=0.04, respectively). There was weak evidence of an increased risk of SIA in mothers aged less than 20 years compared with mothers aged 20 to 29 years (RR=1.3, 95% CrI: 1.0 to 1.8). CONCLUSION: This study found no evidence of a temporal trend in the prevalence of SIA, duodenal atresia or JIA, although SIA and duodenal atresia prevalence varied significantly between registers.en_GB
dc.description.abstractThe epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe.
dc.description.abstractCases of SIA delivered during January 1990 to December 2006 notified to 20 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept.
dc.description.abstractIn total 1133 SIA cases were reported among 5126, 164 registered births. Of 1044 singleton cases, 215 (20.6%) cases were associated with a chromosomal anomaly. Of 829 singleton SIA cases with normal karyotype, 221 (26.7%) were associated with other structural anomalies. Considering cases with normal karyotype, the total prevalence per 10 000 births was 1.6 (95% CI 1.5 to 1.7) for SIA, 0.9 (95% CI 0.8 to 1.0) for duodenal atresia and 0.7 (95% CI 0.7 to 0.8) for jejunoileal atresia (JIA). There was no significant trend in SIA, duodenal atresia or JIA prevalence over time (RR=1.0, 95% credible interval (CrI): 1.0 to 1.0 for each), but SIA and duodenal atresia prevalence varied by geographical location (p=0.03 and p=0.04, respectively). There was weak evidence of an increased risk of SIA in mothers aged less than 20 years compared with mothers aged 20 to 29 years (RR=1.3, 95% CrI: 1.0 to 1.8).
dc.description.abstractThis study found no evidence of a temporal trend in the prevalence of SIA, duodenal atresia or JIA, although SIA and duodenal atresia prevalence varied significantly between registers.
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22933095en_GB
dc.rightsArchived with thanks to Archives of disease in childhood. Fetal and neonatal editionen_GB
dc.subjectNEONATEen_GB
dc.subject.meshDuodenal Obstruction
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIntestinal Atresia
dc.subject.meshIntestine, Small
dc.subject.meshMaternal Age
dc.subject.meshPregnancy
dc.subject.meshPregnancy Outcome
dc.subject.meshPrevalence
dc.subject.meshProportional Hazards Models
dc.subject.meshRegistries
dc.subject.otherBIRTH DEFECTSen_GB
dc.subject.otherGASTROINTESTINAL DISORDERen_GB
dc.titleEpidemiology of small intestinal atresia in Europe: a register-based study.en_GB
dc.typeArticleen
dc.contributor.departmentInstitute of Health & Society, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, England, UK.en_GB
dc.identifier.journalArchives of disease in childhood. Fetal and neonatal editionen_GB
html.description.abstractThe epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe.
html.description.abstractCases of SIA delivered during January 1990 to December 2006 notified to 20 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept.
html.description.abstractIn total 1133 SIA cases were reported among 5126, 164 registered births. Of 1044 singleton cases, 215 (20.6%) cases were associated with a chromosomal anomaly. Of 829 singleton SIA cases with normal karyotype, 221 (26.7%) were associated with other structural anomalies. Considering cases with normal karyotype, the total prevalence per 10 000 births was 1.6 (95% CI 1.5 to 1.7) for SIA, 0.9 (95% CI 0.8 to 1.0) for duodenal atresia and 0.7 (95% CI 0.7 to 0.8) for jejunoileal atresia (JIA). There was no significant trend in SIA, duodenal atresia or JIA prevalence over time (RR=1.0, 95% credible interval (CrI): 1.0 to 1.0 for each), but SIA and duodenal atresia prevalence varied by geographical location (p=0.03 and p=0.04, respectively). There was weak evidence of an increased risk of SIA in mothers aged less than 20 years compared with mothers aged 20 to 29 years (RR=1.3, 95% CrI: 1.0 to 1.8).
html.description.abstractThis study found no evidence of a temporal trend in the prevalence of SIA, duodenal atresia or JIA, although SIA and duodenal atresia prevalence varied significantly between registers.


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