Show simple item record

dc.contributor.authorAherne, Noel J
dc.contributor.authorRangaswamy, Guhan
dc.contributor.authorThirion, Pierre
dc.date.accessioned2014-08-01T11:31:21Z
dc.date.available2014-08-01T11:31:21Z
dc.date.issued2013-08-05
dc.identifier.citationAherne NJ, Rangaswamy G, Thirion P. Prostate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation. Case Rep Urol. 2013, 2013:405343 Case Rep Urolen_GB
dc.identifier.issn2090-696X
dc.identifier.pmid23984174
dc.identifier.doi10.1155/2013/405343
dc.identifier.urihttp://hdl.handle.net/10147/324092
dc.description.abstractHolt-Oram syndrome is an autosomal dominant disorder which is caused by mutations of TBX5 and is characterised by cardiac and skeletal abnormalities. TBX5 is part of the T-box gene family and is thought to upregulate tumour cell proliferation and metastasis when mutated. We report the first clinical case of prostate cancer in an individual with Holt Oram syndrome.
dc.language.isoenen
dc.publisherHindawi Publishing Corp.en_GB
dc.rightsArchived with thanks to Case reports in urologyen_GB
dc.subjectPROSTATE CANCERen_GB
dc.subjectGENETICSen_GB
dc.subject.otherHOLT-ORAM SYNDROMEen_GB
dc.titleProstate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour, NSW 2450, Australia.en_GB
dc.identifier.journalCase reports in urologyen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
refterms.dateFOA2018-08-24T14:37:38Z
html.description.abstractHolt-Oram syndrome is an autosomal dominant disorder which is caused by mutations of TBX5 and is characterised by cardiac and skeletal abnormalities. TBX5 is part of the T-box gene family and is thought to upregulate tumour cell proliferation and metastasis when mutated. We report the first clinical case of prostate cancer in an individual with Holt Oram syndrome.


Files in this item

Thumbnail
Name:
Rangaswamy et al (2013).pdf
Size:
1.389Mb
Format:
PDF
Description:
Main Article

This item appears in the following Collection(s)

Show simple item record