Prostate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation.

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Authors
Aherne, Noel J
Rangaswamy, Guhan
Thirion, Pierre
Affiliation
Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour, NSW 2450, Australia.
Issue Date
2013-08-05
Keywords
PROSTATE CANCER
GENETICS
Local subject classification
HOLT-ORAM SYNDROME

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Citation
Aherne NJ, Rangaswamy G, Thirion P. Prostate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation. Case Rep Urol. 2013, 2013:405343 Case Rep Urol
Publisher
Hindawi Publishing Corp.
Journal
Case reports in urology
URI
http://hdl.handle.net/10147/324092
DOI
10.1155/2013/405343
PubMed ID
23984174
Abstract
Holt-Oram syndrome is an autosomal dominant disorder which is caused by mutations of TBX5 and is characterised by cardiac and skeletal abnormalities. TBX5 is part of the T-box gene family and is thought to upregulate tumour cell proliferation and metastasis when mutated. We report the first clinical case of prostate cancer in an individual with Holt Oram syndrome.
Item Type
Article
Language
en
ISSN
2090-696X
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