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    Prostate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation.

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    Rangaswamy et al (2013).pdf
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    Authors
    Aherne, Noel J
    Rangaswamy, Guhan
    Thirion, Pierre
    Affiliation
    Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour, NSW 2450, Australia.
    Issue Date
    2013-08-05
    Keywords
    PROSTATE CANCER
    GENETICS
    Local subject classification
    HOLT-ORAM SYNDROME
    
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    Citation
    Aherne NJ, Rangaswamy G, Thirion P. Prostate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation. Case Rep Urol. 2013, 2013:405343 Case Rep Urol
    Publisher
    Hindawi Publishing Corp.
    Journal
    Case reports in urology
    URI
    http://hdl.handle.net/10147/324092
    DOI
    10.1155/2013/405343
    PubMed ID
    23984174
    Abstract
    Holt-Oram syndrome is an autosomal dominant disorder which is caused by mutations of TBX5 and is characterised by cardiac and skeletal abnormalities. TBX5 is part of the T-box gene family and is thought to upregulate tumour cell proliferation and metastasis when mutated. We report the first clinical case of prostate cancer in an individual with Holt Oram syndrome.
    Item Type
    Article
    Language
    en
    ISSN
    2090-696X
    ae974a485f413a2113503eed53cd6c53
    10.1155/2013/405343
    Scopus Count
    Collections
    St. Luke's Radiation Oncology Network, Dublin

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