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dc.contributor.authorMastroiacovo, Pierpaolo
dc.contributor.authorLisi, Alessandra
dc.contributor.authorCastilla, Eduardo E
dc.contributor.authorMartínez-Frías, María-Luisa
dc.contributor.authorBermejo, Eva
dc.contributor.authorMarengo, Lisa
dc.contributor.authorKucik, Jim
dc.contributor.authorSiffel, Csaba
dc.contributor.authorHalliday, Jane
dc.contributor.authorGatt, Miriam
dc.contributor.authorAnnerèn, Göran
dc.contributor.authorBianchi, Fabrizio
dc.contributor.authorCanessa, M Aurora
dc.contributor.authorDanderfer, Ron
dc.contributor.authorde Walle, Hermien
dc.contributor.authorHarris, John
dc.contributor.authorLi, Zhu
dc.contributor.authorLowry, R Brian
dc.contributor.authorMcDonell, Robert
dc.contributor.authorMerlob, Paul
dc.contributor.authorMetneki, Julia
dc.contributor.authorMutchinick, Osvaldo
dc.contributor.authorRobert-Gnansia, Elisabeth
dc.contributor.authorScarano, Gioacchino
dc.contributor.authorSipek, Antonin
dc.contributor.authorPötzsch, Simone
dc.contributor.authorSzabova, Elena
dc.contributor.authorYevtushok, Lyubov
dc.date.accessioned2014-07-31T14:13:04Z
dc.date.available2014-07-31T14:13:04Z
dc.date.issued2007-04-01
dc.identifier.citationMastroiacovo P et al. Gastroschisis and associated defects: an international study. Am. J. Med. Genet. A 2007, 143 (7):660-71en_GB
dc.identifier.issn1552-4825
dc.identifier.pmid17357116
dc.identifier.doi10.1002/ajmg.a.31607
dc.identifier.urihttp://hdl.handle.net/10147/324055
dc.descriptionOur objective was to evaluate the frequency and type of malformations associated with gastroschisis in a large pool of international data, to identify malformation patterns, and to evaluate the role of maternal age in non-isolated cases. Case-by-case information from 24 registries, all members of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), were evaluated. After the exclusion of other abdominal wall defects cases were classified as: (a) isolated; (b) recognizable syndrome, chromosomal or not; (c) multiple congenital anomalies (MCA). Our results showed that out of 3,322 total cases 469 non-isolated cases were registered (14.1%): 41 chromosomal syndromes, 24 other syndromes, and 404 MCA. Among MCA four groups of anomalies were most frequent: CNS (4.5%), cardio-vascular (2.5%), limb (2.2%), and kidney anomalies (1.9%). No similar patterns emerged except two patterns resembling limb-body wall complex and OEIS. In both of them the gastroschisis could be however misclassified. Chromosomal trisomies and possibly non-syndromic MCA are associated with an older maternal age more than isolated cases. On consideration of our data and the most valid studies published in the literature, the best estimate of the proportion of gastroschisis associated with major unrelated defects is about 10%, with a few cases associated to recognizable syndromes. Recognized syndromes with gastroschisis seem to be so exceptional that the well documented and validated cases are worth being published as interesting case report. An appropriate case definition in etiological studies should include only isolated gastroschisis after an appropriate definition of isolated and non-isolated cases and a thorough case-by-case review.en_GB
dc.description.abstractOur objective was to evaluate the frequency and type of malformations associated with gastroschisis in a large pool of international data, to identify malformation patterns, and to evaluate the role of maternal age in non-isolated cases. Case-by-case information from 24 registries, all members of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), were evaluated. After the exclusion of other abdominal wall defects cases were classified as: (a) isolated; (b) recognizable syndrome, chromosomal or not; (c) multiple congenital anomalies (MCA). Our results showed that out of 3,322 total cases 469 non-isolated cases were registered (14.1%): 41 chromosomal syndromes, 24 other syndromes, and 404 MCA. Among MCA four groups of anomalies were most frequent: CNS (4.5%), cardio-vascular (2.5%), limb (2.2%), and kidney anomalies (1.9%). No similar patterns emerged except two patterns resembling limb-body wall complex and OEIS. In both of them the gastroschisis could be however misclassified. Chromosomal trisomies and possibly non-syndromic MCA are associated with an older maternal age more than isolated cases. On consideration of our data and the most valid studies published in the literature, the best estimate of the proportion of gastroschisis associated with major unrelated defects is about 10%, with a few cases associated to recognizable syndromes. Recognized syndromes with gastroschisis seem to be so exceptional that the well documented and validated cases are worth being published as interesting case report. An appropriate case definition in etiological studies should include only isolated gastroschisis after an appropriate definition of isolated and non-isolated cases and a thorough case-by-case review.
dc.language.isoenen
dc.rightsArchived with thanks to American journal of medical genetics. Part Aen_GB
dc.subjectGENETICSen_GB
dc.subject.meshAbnormalities, Multiple
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshGastroschisis
dc.subject.meshHumans
dc.subject.otherBIRTH DEFECTSen_GB
dc.subject.otherABDOMENen_GB
dc.titleGastroschisis and associated defects: an international study.en_GB
dc.typeArticleen
dc.contributor.departmentCentre of the International Clearinghouse for Birth Defects Surveillance and Research, Rome, Italy. icbd@icbd.orgen_GB
dc.identifier.journalAmerican journal of medical genetics. Part Aen_GB
html.description.abstractOur objective was to evaluate the frequency and type of malformations associated with gastroschisis in a large pool of international data, to identify malformation patterns, and to evaluate the role of maternal age in non-isolated cases. Case-by-case information from 24 registries, all members of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), were evaluated. After the exclusion of other abdominal wall defects cases were classified as: (a) isolated; (b) recognizable syndrome, chromosomal or not; (c) multiple congenital anomalies (MCA). Our results showed that out of 3,322 total cases 469 non-isolated cases were registered (14.1%): 41 chromosomal syndromes, 24 other syndromes, and 404 MCA. Among MCA four groups of anomalies were most frequent: CNS (4.5%), cardio-vascular (2.5%), limb (2.2%), and kidney anomalies (1.9%). No similar patterns emerged except two patterns resembling limb-body wall complex and OEIS. In both of them the gastroschisis could be however misclassified. Chromosomal trisomies and possibly non-syndromic MCA are associated with an older maternal age more than isolated cases. On consideration of our data and the most valid studies published in the literature, the best estimate of the proportion of gastroschisis associated with major unrelated defects is about 10%, with a few cases associated to recognizable syndromes. Recognized syndromes with gastroschisis seem to be so exceptional that the well documented and validated cases are worth being published as interesting case report. An appropriate case definition in etiological studies should include only isolated gastroschisis after an appropriate definition of isolated and non-isolated cases and a thorough case-by-case review.


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