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dc.contributor.authorWijers, CHW
dc.contributor.authorvan Rooij, IALM
dc.contributor.authorBakker, MK
dc.contributor.authorMarcelis, CLM
dc.contributor.authorAddor, MC
dc.contributor.authorBarisic, I
dc.contributor.authorBéres, J
dc.contributor.authorBianca, S
dc.contributor.authorBianchi, F
dc.contributor.authorCalzolari, E
dc.contributor.authorGreenlees, R
dc.contributor.authorLelong, N
dc.contributor.authorLatos-Bielenska, A
dc.contributor.authorDias, CM
dc.contributor.authorMcDonnell, R
dc.contributor.authorMullaney, C
dc.contributor.authorNelen, V
dc.contributor.authorO'Mahony, M
dc.contributor.authorQueisser-Luft, A
dc.contributor.authorRankin, J
dc.contributor.authorZymak-Zakutnia, N
dc.contributor.authorde Blaauw, I
dc.contributor.authorRoeleveld, N
dc.contributor.authorde Walle, HEK
dc.date.accessioned2014-07-29T11:00:49Zen
dc.date.available2014-07-29T11:00:49Zen
dc.date.issued2014-07-29en
dc.identifier.citationWijers CHW et al. Anorectal malformations and pregnancy-related disorders: a registry-based case-control study in 17 European regions. BJOG 2013, 120 (9):1066en_GB
dc.identifier.issn14700328en
dc.identifier.doi10.1111/1471-0528.12235en
dc.identifier.urihttp://hdl.handle.net/10147/323872en
dc.descriptionOBJECTIVE: To identify pregnancy-related risk factors for different manifestations of congenital anorectal malformations (ARMs). DESIGN: A population-based case-control study. SETTING: Seventeen EUROCAT (European Surveillance of Congenital Anomalies) registries, 1980-2008. POPULATION: The study population consisted of 1417 cases with ARM, including 648 cases of isolated ARM, 601 cases of ARM with additional congenital anomalies, and 168 cases of ARM-VACTERL (vertebral, anal, cardiac, tracheo-esophageal, renal, and limb defects), along with 13 371 controls with recognised syndromes or chromosomal abnormalities. METHODS: Multiple logistic regression analyses were used to calculate adjusted odds ratios (ORs) for potential risk factors for ARM, such as fertility treatment, multiple pregnancy, primiparity, maternal illnesses during pregnancy, and pregnancy-related complications. MAIN OUTCOME MEASURES: Adjusted ORs for pregnancy-related risk factors for ARM. RESULTS: The ARM cases were more likely to be firstborn than the controls (OR 1.6, 95% CI 1.4-1.8). Fertility treatment and being one of twins or triplets seemed to increase the risk of ARM in cases with additional congenital anomalies or VACTERL (ORs ranging from 1.6 to 2.5). Maternal fever during pregnancy and pre-eclampsia were only associated with ARM when additional congenital anomalies were present (OR 3.9, 95% CI 1.3-11.6; OR 3.4, 95% CI 1.6-7.1, respectively), whereas maternal epilepsy during pregnancy resulted in a five-fold elevated risk of all manifestations of ARM (OR 5.1, 95% CI 1.7-15.6). CONCLUSIONS: This large European study identified maternal epilepsy, fertility treatment, multiple pregnancy, primiparity, pre-eclampsia, and maternal fever during pregnancy as potential risk factors primarily for complex manifestations of ARM with additional congenital anomalies and VACTERL. © 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.en_GB
dc.language.isoenen
dc.relation.urlhttp://doi.wiley.com/10.1111/1471-0528.12235en_GB
dc.rightsArchived with thanks to BJOG: An International Journal of Obstetrics & Gynaecologyen_GB
dc.subjectPREGNANCYen_GB
dc.subject.otherBIRTH DEFECTSen_GB
dc.subject.otherPUBLIC HEALTH DEPARTMENTen
dc.subject.otherCONGENITAL ANOMALYen
dc.subject.otherHEALTH PROTECTIONen
dc.titleAnorectal malformations and pregnancy-related disorders: a registry-based case-control study in 17 European regionsen_GB
dc.typeArticleen
dc.identifier.journalBJOG: An International Journal of Obstetrics & Gynaecologyen_GB


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