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    DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells.

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    Authors
    Martin, Lynn M
    Marples, Brian
    Davies, Anthony M
    Atzberger, Ann
    Edwards, Connla
    Lynch, Thomas H
    Hollywood, Donal
    Marignol, Laure
    Affiliation
    Radiation and Urologic Oncology, Prostate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, Trinity College Dublin, Dublin 8, Ireland.
    Issue Date
    2013-07-10
    Keywords
    CANCER
    Local subject classification
    CELL BIOLOGY
    MeSH
    Carcinoma
    Cell Line, Tumor
    Cell Nucleus
    Cell Survival
    DNA Mismatch Repair
    DNA-Binding Proteins
    Endometrial Neoplasms
    Female
    G2 Phase Cell Cycle Checkpoints
    Gene Expression
    Histones
    Humans
    MutS Homolog 2 Protein
    Radiation Tolerance
    Recombinational DNA Repair
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    Citation
    Martin LM et al. DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells. 2013, 335 (1):19-25 Cancer Lett.
    Publisher
    Elsevier Ireland Ltd
    Journal
    Cancer letters
    URI
    http://hdl.handle.net/10147/323264
    DOI
    10.1016/j.canlet.2013.01.046
    PubMed ID
    23376256
    Abstract
    DNA repair and G2-phase cell cycle checkpoint responses are involved in the manifestation of hyper-radiosensitivity (HRS). The low-dose radioresponse of MSH2 isogenic endometrial carcinoma cell lines was examined. Defects in cell cycle checkpoint activation and the DNA damage response in irradiated cells (0.2 Gy) were evaluated. HRS was expressed solely in MSH2+ cells and was associated with efficient activation of the early G2-phase cell cycle checkpoint. Maintenance of the arrest was associated with persistent MRE11, γH2AX, RAD51 foci at 2 h after irradiation. Persistent MRE11 and RAD51 foci were also evident 24 h after 0.2 Gy. MSH2 significantly enhances cell radiosensitivity to low dose IR.
    Item Type
    Article
    Language
    en
    ISSN
    1872-7980
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.canlet.2013.01.046
    Scopus Count
    Collections
    St. Luke's Radiation Oncology Network, Dublin

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