The relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth.
dc.contributor.author | Walsh, Jennifer M | |
dc.contributor.author | McGowan, Ciara A | |
dc.contributor.author | Kilbane, Mark | |
dc.contributor.author | McKenna, Malachi J | |
dc.contributor.author | McAuliffe, Fionnuala M | |
dc.date.accessioned | 2014-04-10T09:36:09Z | |
dc.date.available | 2014-04-10T09:36:09Z | |
dc.date.issued | 2013-05 | |
dc.identifier.citation | The relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth. 2013, 20 (5):536-41 Reprod Sci | en_GB |
dc.identifier.issn | 1933-7205 | |
dc.identifier.pmid | 22968764 | |
dc.identifier.doi | 10.1177/1933719112459222 | |
dc.identifier.uri | http://hdl.handle.net/10147/315564 | |
dc.description.abstract | Evidence for a role of vitamin D in maintaining normal glucose homeostasis is inconclusive. We sought to clarify the relationship between maternal and fetal insulin resistance and vitamin D status. This is a prospective cohort study of 60 caucasian pregnant women. Concentrations of 25-hydroxyvitamin D (25-OHD), glucose, insulin, and leptin were measured in early pregnancy and at 28 weeks. Ultrasound at 34 weeks assessed fetal anthropometry including abdominal wall width, a marker of fetal adiposity. At delivery birth weight was recorded and fetal 25-OHD, glucose, C-peptide, and leptin measured in cord blood. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) equation. We found that those with lower 25-OHD in early pregnancy had higher HOMA indices at 28 weeks, (r = -.32, P = .02). No significant relationship existed between maternal or fetal leptin and 25-OHD, or between maternal or fetal 25-OHD and fetal anthropometry or birth weight. The incidence of vitamin D deficiency was high at each time point (15%-45%). These findings lend support to routine antenatal supplementation with vitamin D in at risk populations. | |
dc.language.iso | en | en |
dc.relation.url | http://rsx.sagepub.com/content/20/5/536.long | en_GB |
dc.rights | Archived with thanks to Reproductive sciences (Thousand Oaks, Calif.) | en_GB |
dc.subject | PREGNANCY | en_GB |
dc.subject | NUTRITION | en_GB |
dc.subject.mesh | Adiposity | |
dc.subject.mesh | Biological Markers | |
dc.subject.mesh | Blood Glucose | |
dc.subject.mesh | Female | |
dc.subject.mesh | Fetal Blood | |
dc.subject.mesh | Fetal Development | |
dc.subject.mesh | Fetal Macrosomia | |
dc.subject.mesh | Gestational Age | |
dc.subject.mesh | Homeostasis | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Insulin | |
dc.subject.mesh | Insulin Resistance | |
dc.subject.mesh | Leptin | |
dc.subject.mesh | Longitudinal Studies | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Prospective Studies | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Vitamin D | |
dc.subject.mesh | Vitamin D Deficiency | |
dc.subject.other | FOETAL DEVELOPMENT | en_GB |
dc.title | The relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth. | en_GB |
dc.type | Article | en |
dc.contributor.department | UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland | en_GB |
dc.identifier.journal | Reproductive sciences (Thousand Oaks, Calif.) | en_GB |
dc.description.funding | HRB Health Research Board | en |
dc.description.province | Leinster | en |
dc.description.peer-review | peer-review | en |
html.description.abstract | Evidence for a role of vitamin D in maintaining normal glucose homeostasis is inconclusive. We sought to clarify the relationship between maternal and fetal insulin resistance and vitamin D status. This is a prospective cohort study of 60 caucasian pregnant women. Concentrations of 25-hydroxyvitamin D (25-OHD), glucose, insulin, and leptin were measured in early pregnancy and at 28 weeks. Ultrasound at 34 weeks assessed fetal anthropometry including abdominal wall width, a marker of fetal adiposity. At delivery birth weight was recorded and fetal 25-OHD, glucose, C-peptide, and leptin measured in cord blood. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) equation. We found that those with lower 25-OHD in early pregnancy had higher HOMA indices at 28 weeks, (r = -.32, P = .02). No significant relationship existed between maternal or fetal leptin and 25-OHD, or between maternal or fetal 25-OHD and fetal anthropometry or birth weight. The incidence of vitamin D deficiency was high at each time point (15%-45%). These findings lend support to routine antenatal supplementation with vitamin D in at risk populations. |