Issue Date
2013-05Keywords
NEONATENUTRITION
Local subject classification
IMMUNOLOGYMeSH
Adaptive ImmunityAutoimmune Diseases
Child
Dietary Supplements
Female
Humans
Immunity, Innate
Infant, Newborn
Maternal-Fetal Exchange
Pregnancy
Vitamin D
Vitamin D Deficiency
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Show full item recordCitation
Vitamin D and neonatal immune function. 2013, 26 (7):639-46 J. Matern. Fetal. Neonatal. Med.Journal
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansDOI
10.3109/14767058.2012.746304PubMed ID
23131172Additional Links
http://informahealthcare.com/doi/abs/10.3109/14767058.2012.746304Abstract
Vitamin D deficiency is widespread in the neonatal and paediatric population of northern latitudes, particularly in children of African, Middle Eastern and Asian ethnicity. This is associated with diminished immune function and increases the risk of Th1 autoimmune diseases like type 1 diabetes. Epidermiological studies have also shown a link between vitamin D deficiency in children and a more severe course of illness with lower respiratory tract infection or Respiratory Syncitial Virus (RSV) bronchiolitis. The mechanism by which vitamin D enhances immunity is complex. It acts through the innate immune system by inducing antimicrobial peptides in epithelial cells, neutrophils and macrophages. The role of Vitamin D in neonatal and paediatric immunomodulation requires further study.Item Type
ArticleLanguage
enISSN
1476-4954ae974a485f413a2113503eed53cd6c53
10.3109/14767058.2012.746304
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