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    Vitamin D and neonatal immune function.

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    Authors
    Clancy, N
    Onwuneme, C
    Carroll, A
    McCarthy, R
    McKenna, M J
    Murphy, N
    Molloy, E J
    Issue Date
    2013-05
    Keywords
    NEONATE
    NUTRITION
    Local subject classification
    IMMUNOLOGY
    MeSH
    Adaptive Immunity
    Autoimmune Diseases
    Child
    Dietary Supplements
    Female
    Humans
    Immunity, Innate
    Infant, Newborn
    Maternal-Fetal Exchange
    Pregnancy
    Vitamin D
    Vitamin D Deficiency
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    Citation
    Vitamin D and neonatal immune function. 2013, 26 (7):639-46 J. Matern. Fetal. Neonatal. Med.
    Journal
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
    URI
    http://hdl.handle.net/10147/315562
    DOI
    10.3109/14767058.2012.746304
    PubMed ID
    23131172
    Additional Links
    http://informahealthcare.com/doi/abs/10.3109/14767058.2012.746304
    Abstract
    Vitamin D deficiency is widespread in the neonatal and paediatric population of northern latitudes, particularly in children of African, Middle Eastern and Asian ethnicity. This is associated with diminished immune function and increases the risk of Th1 autoimmune diseases like type 1 diabetes. Epidermiological studies have also shown a link between vitamin D deficiency in children and a more severe course of illness with lower respiratory tract infection or Respiratory Syncitial Virus (RSV) bronchiolitis. The mechanism by which vitamin D enhances immunity is complex. It acts through the innate immune system by inducing antimicrobial peptides in epithelial cells, neutrophils and macrophages. The role of Vitamin D in neonatal and paediatric immunomodulation requires further study.
    Item Type
    Article
    Language
    en
    ISSN
    1476-4954
    ae974a485f413a2113503eed53cd6c53
    10.3109/14767058.2012.746304
    Scopus Count
    Collections
    National Maternity Hospital Holles St.

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