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    Toll-like receptors in neonatal sepsis.

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    Authors
    O'Hare, Fiona M
    William Watson, R
    Molloy, Eleanor J
    Issue Date
    2013-06
    Keywords
    NEONATE
    Local subject classification
    IMMUNOLOGY
    SEPSIS
    MeSH
    Animals
    Genetic Predisposition to Disease
    Host-Pathogen Interactions
    Humans
    Immunity, Innate
    Immunologic Factors
    Infant, Newborn
    Mycoses
    Probiotics
    Sepsis
    Signal Transduction
    Toll-Like Receptor 2
    Toll-Like Receptor 4
    Toll-Like Receptors
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    Citation
    Toll-like receptors in neonatal sepsis. 2013, 102 (6):572-8 Acta Paediatr.
    Journal
    Acta paediatrica
    URI
    http://hdl.handle.net/10147/315558
    DOI
    10.1111/apa.12201
    PubMed ID
    23419040
    Additional Links
    http://onlinelibrary.wiley.com/doi/10.1111/apa.12201/abstract
    Abstract
    Toll-like receptors are vital transmembrane receptors that initiate the innate immune response to many micro-organisms. The discovery of these receptors has improved our understanding of host-pathogen interactions, and these receptors play an important role in the pathogenesis of multiple neonatal conditions such as sepsis and brain injury. Toll-like receptors, especially TLRs 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.
    Item Type
    Article
    Language
    en
    ISSN
    1651-2227
    ae974a485f413a2113503eed53cd6c53
    10.1111/apa.12201
    Scopus Count
    Collections
    National Maternity Hospital Holles St.

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