Local subject classificationIMMUNOLOGY
Genetic Predisposition to Disease
Toll-Like Receptor 2
Toll-Like Receptor 4
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CitationToll-like receptors in neonatal sepsis. 2013, 102 (6):572-8 Acta Paediatr.
AbstractToll-like receptors are vital transmembrane receptors that initiate the innate immune response to many micro-organisms. The discovery of these receptors has improved our understanding of host-pathogen interactions, and these receptors play an important role in the pathogenesis of multiple neonatal conditions such as sepsis and brain injury. Toll-like receptors, especially TLRs 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.