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dc.contributor.authorO’Keeffe, Linda M
dc.contributor.authorGreene, Richard A
dc.contributor.authorKearney, Patricia M
dc.date.accessioned2014-04-07T08:30:45Z
dc.date.available2014-04-07T08:30:45Z
dc.date.issued2014-01-02
dc.identifier.citationSystematic Reviews. 2014 Jan 02;3(1):1en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/2046-4053-3-1
dc.identifier.urihttp://hdl.handle.net/10147/315447
dc.description.abstractAbstract Background Consensus has not been reached on safe alcohol consumption recommendations during pregnancy. The National Institutes for Care and Health Excellence (NICE) in the UK suggest that one to two drinks not more than twice per week is safe. However, the speech and language effects of even low levels of alcohol use among offspring are unknown. The aim of this study was to review systematically the evidence on studies of the effect of low to moderate levels of alcohol consumption during pregnancy (up to 70 grams of alcohol per week) compared to abstinence on speech and language outcomes in children. Methods Using medical subject headings, PubMed, Web of knowledge, Scopus, Embase, Cinahl and the Cochrane Library were searched from their inception up to March 2012. Case control and cohort studies were included. Two assessors independently reviewed titles, abstracts and full articles, extracted data and assessed quality. Results A total of 1,397 titles and abstracts were reviewed of which 51 full texts were retrieved. Three cohort studies totaling 10,642 women met the inclusion criteria. All three studies, (United States (2) and Australia (1)) indicated that language was not impaired as a result of low to moderate alcohol consumption during pregnancy. Two studies were judged to be of low quality based on a six-item bias classification tool. Due to heterogeneity, results could not be meta-analyzed. Conclusion Studies included in this review do not provide sufficient evidence to confirm or refute an association between low to moderate alcohol use during pregnancy and speech and language outcomes in children. High quality, population based studies are required to establish the safety of low to moderate levels of alcohol use such as those set out by the NICE guidelines in the UK.
dc.language.isoenen
dc.subjectPREGNANT WOMENen_GB
dc.subjectPREGNANCYen_GB
dc.subjectSMOKINGen_GB
dc.subjectSPEECH & LANGUAGE THERAPYen_GB
dc.titleThe effect of moderate gestational alcohol consumption during pregnancy on speech and language outcomes in children: a systematic reviewen_GB
dc.typeSystematic Reviewen
dc.language.rfc3066en
dc.rights.holderLinda M O’Keeffe et al.; licensee BioMed Central Ltd.
dc.description.statusPeer Reviewed
dc.date.updated2014-04-05T11:18:49Z
refterms.dateFOA2018-08-24T00:19:12Z
html.description.abstractAbstract Background Consensus has not been reached on safe alcohol consumption recommendations during pregnancy. The National Institutes for Care and Health Excellence (NICE) in the UK suggest that one to two drinks not more than twice per week is safe. However, the speech and language effects of even low levels of alcohol use among offspring are unknown. The aim of this study was to review systematically the evidence on studies of the effect of low to moderate levels of alcohol consumption during pregnancy (up to 70 grams of alcohol per week) compared to abstinence on speech and language outcomes in children. Methods Using medical subject headings, PubMed, Web of knowledge, Scopus, Embase, Cinahl and the Cochrane Library were searched from their inception up to March 2012. Case control and cohort studies were included. Two assessors independently reviewed titles, abstracts and full articles, extracted data and assessed quality. Results A total of 1,397 titles and abstracts were reviewed of which 51 full texts were retrieved. Three cohort studies totaling 10,642 women met the inclusion criteria. All three studies, (United States (2) and Australia (1)) indicated that language was not impaired as a result of low to moderate alcohol consumption during pregnancy. Two studies were judged to be of low quality based on a six-item bias classification tool. Due to heterogeneity, results could not be meta-analyzed. Conclusion Studies included in this review do not provide sufficient evidence to confirm or refute an association between low to moderate alcohol use during pregnancy and speech and language outcomes in children. High quality, population based studies are required to establish the safety of low to moderate levels of alcohol use such as those set out by the NICE guidelines in the UK.


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