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    Tensile and compressive properties of fresh human carotid atherosclerotic plaques.

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    Authors
    Maher, Eoghan
    Creane, Arthur
    Sultan, Sherif
    Hynes, Niamh
    Lally, Caitríona
    Kelly, Daniel J
    Affiliation
    Trinity Centre for Bioengineering, School of Engineering, Trinity College Dublin, Dublin, Ireland.
    Issue Date
    2009-12-11
    MeSH
    Aged
    Carotid Arteries
    Carotid Stenosis
    Compressive Strength
    Computer Simulation
    Elastic Modulus
    Female
    Hardness
    Humans
    Male
    Models, Cardiovascular
    Stress, Mechanical
    Tensile Strength
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    Citation
    Tensile and compressive properties of fresh human carotid atherosclerotic plaques. 2009, 42 (16):2760-7 J Biomech
    Publisher
    Journal of biomechanics
    Journal
    Journal of biomechanics
    URI
    http://hdl.handle.net/10147/304743
    DOI
    10.1016/j.jbiomech.2009.07.032
    PubMed ID
    19766226
    Abstract
    Accurate characterisation of the mechanical properties of human atherosclerotic plaque is important for our understanding of the role of vascular mechanics in the development and treatment of atherosclerosis. The majority of previous studies investigating the mechanical properties of human plaque are based on tests of plaque tissue removed following autopsy. This study aims to characterise the mechanical behaviour of fresh human carotid plaques removed during endarterectomy and tested within 2h. A total of 50 radial compressive and 17 circumferential tensile uniaxial tests were performed on samples taken from 14 carotid plaques. The clinical classification of each plaque, as determined by duplex ultrasound is also reported. Plaques were classified as calcified, mixed or echolucent. Experimental data indicated that plaques were highly inhomogeneous; with variations seen in the mechanical properties of plaque obtained from individual donors and between donors. The mean behaviour of samples for each classification indicated that calcified plaques had the stiffest response, while echolucent plaques were the least stiff. Results also indicated that there may be a difference in behaviour of samples taken from different anatomical locations (common, internal and external carotid), however the large variability indicates that more testing is needed to reach significant conclusions. This work represents a step towards a better understanding of the in vivo mechanical behaviour of human atherosclerotic plaque.
    Item Type
    Article
    Language
    en
    ISSN
    1873-2380
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jbiomech.2009.07.032
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