Tensile and compressive properties of fresh human carotid atherosclerotic plaques.
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Affiliation
Trinity Centre for Bioengineering, School of Engineering, Trinity College Dublin, Dublin, Ireland.Issue Date
2009-12-11MeSH
AgedCarotid Arteries
Carotid Stenosis
Compressive Strength
Computer Simulation
Elastic Modulus
Female
Hardness
Humans
Male
Models, Cardiovascular
Stress, Mechanical
Tensile Strength
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Tensile and compressive properties of fresh human carotid atherosclerotic plaques. 2009, 42 (16):2760-7 J BiomechPublisher
Journal of biomechanicsJournal
Journal of biomechanicsDOI
10.1016/j.jbiomech.2009.07.032PubMed ID
19766226Abstract
Accurate characterisation of the mechanical properties of human atherosclerotic plaque is important for our understanding of the role of vascular mechanics in the development and treatment of atherosclerosis. The majority of previous studies investigating the mechanical properties of human plaque are based on tests of plaque tissue removed following autopsy. This study aims to characterise the mechanical behaviour of fresh human carotid plaques removed during endarterectomy and tested within 2h. A total of 50 radial compressive and 17 circumferential tensile uniaxial tests were performed on samples taken from 14 carotid plaques. The clinical classification of each plaque, as determined by duplex ultrasound is also reported. Plaques were classified as calcified, mixed or echolucent. Experimental data indicated that plaques were highly inhomogeneous; with variations seen in the mechanical properties of plaque obtained from individual donors and between donors. The mean behaviour of samples for each classification indicated that calcified plaques had the stiffest response, while echolucent plaques were the least stiff. Results also indicated that there may be a difference in behaviour of samples taken from different anatomical locations (common, internal and external carotid), however the large variability indicates that more testing is needed to reach significant conclusions. This work represents a step towards a better understanding of the in vivo mechanical behaviour of human atherosclerotic plaque.Item Type
ArticleLanguage
enISSN
1873-2380ae974a485f413a2113503eed53cd6c53
10.1016/j.jbiomech.2009.07.032
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